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GPR176 Receptor Antibodies

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Validation of the GPR176 Receptor in transfected HEK293 cells.
GPR176 (non-phospho), G protein-coupled...
The non-phospho-GPR176 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR176. It can be used to detect total GPR176 receptors in Western blots independent of phosphorylation. The GPR176...
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GPR176 is an orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass Gz-alpha and has an agonist-independent basal activity to repress cAMP production. GPR176 is constitutively phosphorylated by GRKs when expressed in HEK293 cells at carboxyl-terminal serine358/serine362 (pS358/pS362-GPR176). Serine358/serine362 is also substrate for PKC mediated phosphorylation. This nomenclature refers to the human GPR176 receptor. This phosphorylation motif is highly conserved across species but refers to pS357/pS361-GPR176 in mice and rats. For more information on GPR176 pharmacology please refer to the IUPHAR database. For further reading refer to:

Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga J, Matsuoka M, Hastings MH, Kiyonari H, Okamura H. Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour. Nat Commun. 2016 Feb 17;7:10583. doi: 10.1038/ncomms10583. PMID: 26882873; PMCID: PMC4757782.

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

GPR176 is an orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass Gz-alpha and has an agonist-independent basal activity to repress cAMP... read more »
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GPR176 Receptor Antibodies

GPR176 is an orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass Gz-alpha and has an agonist-independent basal activity to repress cAMP production. GPR176 is constitutively phosphorylated by GRKs when expressed in HEK293 cells at carboxyl-terminal serine358/serine362 (pS358/pS362-GPR176). Serine358/serine362 is also substrate for PKC mediated phosphorylation. This nomenclature refers to the human GPR176 receptor. This phosphorylation motif is highly conserved across species but refers to pS357/pS361-GPR176 in mice and rats. For more information on GPR176 pharmacology please refer to the IUPHAR database. For further reading refer to:

Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga J, Matsuoka M, Hastings MH, Kiyonari H, Okamura H. Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour. Nat Commun. 2016 Feb 17;7:10583. doi: 10.1038/ncomms10583. PMID: 26882873; PMCID: PMC4757782.

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.

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