![Agonist-induced Serine339/Serine340 phosphorylation of GAL2 Receptor](https://7tmantibodies.com/media/image/ef/43/22/pS339-pS340-GAL2-F1_600x600.png)
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- Order number: 7TM0244C
- Content: 100 µl
- Host: Rabbit
Serine339/Serine340 (S339/S340) is a major phosphorylation site of the GAL2 receptor. The pS339/pS340-GAL2 antibody detects phosphorylation in response to high-efficacy agonists. S339/S340 phosphorylation is a key regulator of GAL2 desensitization, β-arrestin recruitment and internalization.
Alternative Names | GALNR2, Galanin Receptor 2 |
IUPHAR Target ID | 244 |
UniProt ID | O43603 |
Western Blot (WB) | 1:1000 |
Immunocytochemistry (ICC) | - |
Species Reactivity | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Immunogen | A synthetic phosphopeptide derived from human GAL2 around the phosphorylation site Ser339/Ser340. |
Form | Liquid |
Purification | Antigen affinity chromatography |
Storage buffer | Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide |
Storage conditions | short-term 4°C, long-term -20°C |
Figure 1. Agonist-induced Serine339/Serine340 phosphorylation of GAL2 Receptor. Upper panel, HEK293 cells stably expressing the GAL2-Receptor (GAL2) were either not exposed or exposed to 1 µM of specific GAL-Receptor agonist Galanin for 30 minutes. Cells were lysed and immunoblotted with the anti-pS339/pS340-GAL1 antibody (7TM0244C) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-GAL2 antibody to confirm equal loading of the gel.