pT401/pS403-OX2 (phospho-Orexin Receptor 2 Antibody)

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Agonist-induced Threonine401/Serine403 phosphorylation of Orexin Receptor 2

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Order number: 7TM0322A
Content: 100 µl
Host: Rabbit

Threonine401/Serine403 (T401/S403) is a major phosphorylation site of the Orexin receptor 2... more

Threonine401/Serine403 (T401/S403) is a major phosphorylation site of the Orexin receptor 2 (OX2). The pT401/pS403-OX2 antibody detects phosphorylation in response to high-efficacy agonists. T401/S403 phosphorylation is a key regulator of OX2 desensitization, β-arrestin recruitment and internalization.

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Alternative Names OX2R, Hypocretin Receptor 2 IUPHAR Target ID... more

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Alternative Names	OX2R, Hypocretin Receptor 2
IUPHAR Target ID	322
UniProt ID	O43614
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human OX2 around the phosphorylation site Thr401/Ser403.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Threonine401/Serine403 phosphorylation of Orexin Receptor 2. Upper... more

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Figure 1. Agonist-induced Threonine401/Serine403 phosphorylation of Orexin Receptor 2. Upper panel, HEK293 cells stably expressing the Orexin Receptor 2 (OX2) were either not exposed or exposed to 100 nM Orexin-B for 30 minutes. Cells were lysed and immunoblotted with the anti-pT401/pS403-OX2 antibody (7TM0322A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-OX2 antibody to confirm equal loading of the gel.

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