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Immuno-Grade P2Y4 Receptor Antibodies

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Immunohistochemical identification of P2Y Purinoceptor 4 in pancreas
P2Y4 (IHC-grade), P2Y Purinoceptor 4 Antibody
The non-phospho-P2Y4 Receptor Antibody is directed against the distal end of the carboxyl-terminal tail of human P2Y4. It can be used to detect total P2Y4 receptors in Western blots independent of phosphorylation. The non-phospho-P2Y4...
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The human P2Y4 receptor is activated by uridine nucleotidic triphosphates (not diphosphates) and is considered to be a pyrimidinoceptor. ATP is a partial agonist at the human P2Y4 receptor. P2Y4 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine339 (pS339-P2Y4), serine344/serine345 (pS344/pS345-P2Y4) and threonine351 (pT351-P2Y4). S339, S344/pS345 and T351 can also be phosphorylated by PKC. This nomenclature refers to the human P2Y4. For more information on P2Y4 pharmacology please refer to the IUPHAR database. For further reading refer to:

Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev. 2006 Sep;58(3):281-341. doi: 10.1124/pr.58.3.3. PMID: 16968944; PMCID: PMC3471216.

Jacobson KA, Delicado EG, Gachet C, Kennedy C, von Kügelgen I, Li B, Miras-Portugal MT, Novak I, Schöneberg T, Perez-Sen R, Thor D, Wu B, Yang Z, Müller CE. Update of P2Y receptor pharmacology: IUPHAR Review 27. Br J Pharmacol. 2020 Jun;177(11):2413-2433. doi: 10.1111/bph.15005. Epub 2020 Apr 6. PMID: 32037507; PMCID: PMC7205808.

Jacobson KA, Paoletta S, Katritch V, Wu B, Gao ZG, Zhao Q, Stevens RC, Kiselev E. Nucleotides Acting at P2Y Receptors: Connecting Structure and Function. Mol Pharmacol. 2015 Aug;88(2):220-30. doi: 10.1124/mol.114.095711. Epub 2015 Apr 2. PMID: 25837834; PMCID: PMC4518082.

The human P2Y4 receptor is activated by uridine nucleotidic triphosphates (not diphosphates) and is considered to be a pyrimidinoceptor. ATP is a partial agonist at the human P2Y4 receptor. P2Y4... read more »
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Immuno-Grade P2Y4 Receptor Antibodies

The human P2Y4 receptor is activated by uridine nucleotidic triphosphates (not diphosphates) and is considered to be a pyrimidinoceptor. ATP is a partial agonist at the human P2Y4 receptor. P2Y4 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine339 (pS339-P2Y4), serine344/serine345 (pS344/pS345-P2Y4) and threonine351 (pT351-P2Y4). S339, S344/pS345 and T351 can also be phosphorylated by PKC. This nomenclature refers to the human P2Y4. For more information on P2Y4 pharmacology please refer to the IUPHAR database. For further reading refer to:

Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev. 2006 Sep;58(3):281-341. doi: 10.1124/pr.58.3.3. PMID: 16968944; PMCID: PMC3471216.

Jacobson KA, Delicado EG, Gachet C, Kennedy C, von Kügelgen I, Li B, Miras-Portugal MT, Novak I, Schöneberg T, Perez-Sen R, Thor D, Wu B, Yang Z, Müller CE. Update of P2Y receptor pharmacology: IUPHAR Review 27. Br J Pharmacol. 2020 Jun;177(11):2413-2433. doi: 10.1111/bph.15005. Epub 2020 Apr 6. PMID: 32037507; PMCID: PMC7205808.

Jacobson KA, Paoletta S, Katritch V, Wu B, Gao ZG, Zhao Q, Stevens RC, Kiselev E. Nucleotides Acting at P2Y Receptors: Connecting Structure and Function. Mol Pharmacol. 2015 Aug;88(2):220-30. doi: 10.1124/mol.114.095711. Epub 2015 Apr 2. PMID: 25837834; PMCID: PMC4518082.

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