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Premium Immunohistochemistry-Grade 7TM Antibodies

G protein-coupled recptors (GPCRs) and heptahelical receptors (7TMR) are notoriously difficult to detect in fixed tissues using antibodies. For many of these receptors the cellular and subcellular localization remains a major challenge. 7TM Antibodies provides highly-characterized protein binding reagents for selected human and rodent GPCRs, which are well suited for efficient localization in formalin-fixed, paraffin-embedded tissues. Each of these antibodies has gone through advanced validation in transfected cells and native tissues using Western blot and immunohistochemistry. Where ever species cross-reactivity allowed, the verification process included validation using knockout mice (KO-Validated). We strictly adhere to the IUPHAR guidelines for receptor nomenclature.

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Immunohistochemical identification of Glucagon-Like Peptide 2 Receptor in enteric ganglion
GLP2 (IHC-grade), Glucagon-Like Peptide 2...
The non-phospho GLP2 receptor antibody is directed against the distal end of the carboxyl-terminal tail human GLP2 receptor. It can be used to detect total GLP2 receptors in Western blots independent of phosphorylation. It can also be...
$ 375.00 *
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Immunohistochemical identification of Orexin Receptor 1 in pancreas
OX1 (IHC-grade) Orexin Receptor 1 Antibody
The non-phospho OX1 receptor antibody is directed against the distal end of the carboxyl-terminal tail human OX1 receptor. It can also be used to isolate and enrich OX1 receptors from tissue lysates. It also detects OX1 in cultured cells...
$ 375.00 *
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Immunohistochemical identification of Smoothened Receptor in cilia
SMO (IHC-grade), Smoothened Receptor Antibody
The non-phospho SMO receptor antibody is directed against the distal end of the carboxyl-terminal tail human SMO receptor. It can be used to detect total SMO receptors in Western blots independent of phosphorylation. It can also be used...
$ 500.00 *
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Immunohistochemical identification of Secretin Receptor in human cortex
SCTR (IHC-grade), Secretin Receptor Antibody
The non-phospho SCTR receptor antibody is directed against the distal end of the carboxyl-terminal tail human SCTR receptor. It can be used to detect total SCTR receptors in Western blots independent of phosphorylation. It can also be...
$ 375.00 *
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Immunohistochemical identification of FP Prostanoid Receptor in rat cortex
FP (IHC-grade), FP Prostanoid Receptor Antibody
The non-phospho-FP Receptor Antibody is directed against the distal end of the carboxyl-terminal tail of human FP. It can be used to detect total FP receptors in Western blots independent of phosphorylation. The non-phospho-FP antibody...
$ 375.00 *
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Immunohistochemical identification of Proteinase-Activated Receptor 2 in Kidney
PAR2 (IHC-grade), Proteinase-Activated Receptor...
The PAR2 antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human PAR2. It can be used to detect total PAR2 receptors in Western blots independent of phosphorylation. The PAR2 antibody can also be...
$ 375.00 *
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Immunohistochemical identification of the Cannabinoid Receptor 1 in human cortex
CB1 (IHC-grade), Cannabinoid Receptor 1 Antibody
The non-phospho-CB1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human CB1. It can be used to detect total CB1 receptors in Western blots independent of phosphorylation. The CB1 antibody can also...
$ 375.00 *
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Immunohistochemical identification of Calcitonin Receptor-Like Receptor in mouse brain
CALCR (IHC-grade) Calcitonin Receptor-Like...
The non-phospho-CALCR receptor antibody is directed against the distal end of the carboxyl-terminal tail of human CALCR. It can be used to detect total CALCR receptors in Western blots independent of phosphorylation. The CALCR antibody...
$ 375.00 *
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Immunohistochemical identification of Vasopressin Receptor 1B in kidney
V1B (IHC-grade), Vasopressin Receptor 1B Antibody
The non-phospho-V1B Receptor Antibody is directed against the distal end of the carboxyl-terminal tail of human V1B. It can be used to detect total V1B receptors in Western blots independent of phosphorylation. The non-phospho-V1B...
$ 375.00 *
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Immunohistochemical identification of P2Y Purinoceptor 4 in pancreas
P2Y4 (IHC-grade), P2Y Purinoceptor 4 Antibody
The non-phospho-P2Y4 Receptor Antibody is directed against the distal end of the carboxyl-terminal tail of human P2Y4. It can be used to detect total P2Y4 receptors in Western blots independent of phosphorylation. The non-phospho-P2Y4...
$ 375.00 *
Details
NEW
Immunohistochemical identification of Orexin Receptor 2 in pancreas
OX2 (IHC-grade) Orexin Receptor 2 Antibody
The non-phospho OX2 receptor antibody is directed against the distal end of the carboxyl-terminal tail human OX2 receptor. It can be used to detect total OX2 receptors in Western blots independent of phosphorylation. It can also be used...
$ 375.00 *
Details
NEW
Immunohistochemical identification of Neuropeptide Y Receptor 1 in mouse hippocampus
NPY1 (IHC-grade), Neuropeptide Y Receptor 1...
The non-phospho NPY1 receptor antibody is directed against the distal end of the carboxyl-terminal tail human NPY1 receptor. It can be used to detect total NPY1 receptors in Western blots independent of phosphorylation. It can also be...
$ 375.00 *
Details
NEW
Immunohistochemical identification of Neuropeptide Y Receptor 2 in human cortex
NPY2 (IHC-grade), Neuropeptide Y Receptor 2...
The non-phospho NPY2 receptor antibody is directed against the distal end of the carboxyl-terminal tail human NPY2 receptor. It can be used to detect total NPY2 receptors in Western blots independent of phosphorylation. It can also be...
$ 375.00 *
Details
NEW
Immunohistochemical identification of Melanin-Concentrating Hormone Receptor 1 in pancreas
MCH1 (IHC-grade) Melanin-Concentrating Hormone...
The non-phospho MCH1 receptor antibody is directed against the distal end of the carboxyl-terminal tail human MCH1 receptor. It can be used to detect total MCH1 receptors in Western blots independent of phosphorylation. It can also be...
$ 375.00 *
Details
NEW
Immunohistochemical identification of the Hydroxycarboxylic Acid Receptor 1 in pancreas
HCA1 (IHC-grade), Hydroxycarboxylic Acid...
The non-phospho HCA1 receptor antibody is directed against the distal end of the carboxyl-terminal tail human HCA1 receptor. It can be used to detect total HCA1 receptors in Western blots independent of phosphorylation. It can also be...
$ 375.00 *
Details
NEW
Immunohistochemical identification of DP1 Prostanoid receptor 1 in kidney
DP1 (IHC-grade), DP1 Prostanoid Receptor Antibody
The non-phospho-DP1 Receptor Antibody is directed against the distal end of the carboxyl-terminal tail of human DP1. It can be used to detect total DP1 receptors in Western blots independent of phosphorylation. The non-phospho-DP1...
$ 375.00 *
Details
1 From 8

For further reading refer to:

Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1. J Clin Endocrinol Metab. 2008 Nov;93(11):4519-24. doi: 10.1210/jc.2008-1063. Epub 2008 Aug 12. PubMed PMID: 18697876.

Fischer T, Nagel F, Jacobs S, Stumm R, Schulz S. Reassessment of CXCR4 chemokine receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-2. PLoS One. 2008;3(12):e4069. doi: 10.1371/journal.pone.0004069. Epub 2008 Dec 31. PubMed PMID: 19116653; PubMed Central PMCID: PMC2605258.

Lupp A, Hunder A, Petrich A, Nagel F, Doll C, Schulz S. Reassessment of sst(5) somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4. Neuroendocrinology. 2011;94(3):255-64. doi: 10.1159/000329876. Epub 2011 Sep 27. PubMed PMID: 21952553.

Lupp A, Richter N, Doll C, Nagel F, Schulz S. UMB-3, a novel rabbit monoclonal antibody, for assessing μ-opioid receptor expression in mouse, rat and human formalin-fixed and paraffin-embedded tissues. Regul Pept. 2011 Feb 25;167(1):9-13. doi: 10.1016/j.regpep.2010.09.004. Epub 2010 Sep 17. PubMed PMID: 20851148.

Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R. ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin. Cell Rep. 2019 Feb 5;26(6):1473-1488.e9. doi: 10.1016/j.celrep.2019.01.049. PubMed PMID: 30726732.

Sánchez-Alcañiz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, López-Bendito G, Stumm R, Marín O. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron. 2011 Jan 13;69(1):77-90. doi: 10.1016/j.neuron.2010.12.006. PubMed PMID: 21220100.

Casar-Borota O, Heck A, Schulz S, Nesland JM, Ramm-Pettersen J, Lekva T, Alafuzoff I, Bollerslev J. Expression of SSTR2a, but not of SSTRs 1, 3, or 5 in somatotroph adenomas assessed by monoclonal antibodies was reduced by octreotide and correlated with the acute and long-term effects of octreotide. J Clin Endocrinol Metab. 2013 Nov;98(11):E1730-9. doi: 10.1210/jc.2013-2145. Epub 2013 Oct 3. PubMed PMID: 24092823.

Lee M, Lupp A, Mendoza N, Martin N, Beschorner R, Honegger J, Schlegel J, Shively T, Pulz E, Schulz S, Roncaroli F, Pellegata NS. SSTR3 is a putative target for the medical treatment of gonadotroph adenomas of the pituitary. Endocr Relat Cancer. 2015 Feb;22(1):111-9. doi: 10.1530/ERC-14-0472. Epub 2014 Dec 16. PubMed PMID: 25515731.

For further reading refer to: Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the... read more »
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Premium Immunohistochemistry-Grade 7TM Antibodies

For further reading refer to:

Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1. J Clin Endocrinol Metab. 2008 Nov;93(11):4519-24. doi: 10.1210/jc.2008-1063. Epub 2008 Aug 12. PubMed PMID: 18697876.

Fischer T, Nagel F, Jacobs S, Stumm R, Schulz S. Reassessment of CXCR4 chemokine receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-2. PLoS One. 2008;3(12):e4069. doi: 10.1371/journal.pone.0004069. Epub 2008 Dec 31. PubMed PMID: 19116653; PubMed Central PMCID: PMC2605258.

Lupp A, Hunder A, Petrich A, Nagel F, Doll C, Schulz S. Reassessment of sst(5) somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4. Neuroendocrinology. 2011;94(3):255-64. doi: 10.1159/000329876. Epub 2011 Sep 27. PubMed PMID: 21952553.

Lupp A, Richter N, Doll C, Nagel F, Schulz S. UMB-3, a novel rabbit monoclonal antibody, for assessing μ-opioid receptor expression in mouse, rat and human formalin-fixed and paraffin-embedded tissues. Regul Pept. 2011 Feb 25;167(1):9-13. doi: 10.1016/j.regpep.2010.09.004. Epub 2010 Sep 17. PubMed PMID: 20851148.

Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R. ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin. Cell Rep. 2019 Feb 5;26(6):1473-1488.e9. doi: 10.1016/j.celrep.2019.01.049. PubMed PMID: 30726732.

Sánchez-Alcañiz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, López-Bendito G, Stumm R, Marín O. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron. 2011 Jan 13;69(1):77-90. doi: 10.1016/j.neuron.2010.12.006. PubMed PMID: 21220100.

Casar-Borota O, Heck A, Schulz S, Nesland JM, Ramm-Pettersen J, Lekva T, Alafuzoff I, Bollerslev J. Expression of SSTR2a, but not of SSTRs 1, 3, or 5 in somatotroph adenomas assessed by monoclonal antibodies was reduced by octreotide and correlated with the acute and long-term effects of octreotide. J Clin Endocrinol Metab. 2013 Nov;98(11):E1730-9. doi: 10.1210/jc.2013-2145. Epub 2013 Oct 3. PubMed PMID: 24092823.

Lee M, Lupp A, Mendoza N, Martin N, Beschorner R, Honegger J, Schlegel J, Shively T, Pulz E, Schulz S, Roncaroli F, Pellegata NS. SSTR3 is a putative target for the medical treatment of gonadotroph adenomas of the pituitary. Endocr Relat Cancer. 2015 Feb;22(1):111-9. doi: 10.1530/ERC-14-0472. Epub 2014 Dec 16. PubMed PMID: 25515731.

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