Premium Phosphosite-Specific 7TM Antibodies
Your Resource for GPCR Research
Select Your Country of Delivery below

Angiotensin Receptor 2 Antibodies

Close filters
No results were found for the filter!
NEW
Validation of the Angiotensin Receptor 2 in transfected HEK293 cells
AT2 (non-phospho-Angiotensin Receptor 2 Antibody)
The non-phospho-AT2 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human Angiotensin Receptor 2 (AT2). It can be used to detect total AT2 receptors in Western blots independent of phosphorylation....
$ 375.00 *
Details

The angiotensin II type 2 receptor (AT₂R), encoded by AGTR2, is a class A G protein-coupled receptor activated by the endogenous peptides angiotensin II and angiotensin III. Its expression is developmentally regulated and generally more restricted in adults, where it has been detected in the kidneys, adrenal glands, vasculature, and selected brain regions. AT₂R signaling is highly cell type-dependent and has been linked to protein phosphatase activation and the nitric oxide–cGMP pathway. In vascular and renal models, AT₂R activation can promote vasodilation and sodium excretion. Preclinical studies also suggest that it can limit inflammation and fibrosis. AT₂R shows little agonist-induced β-arrestin recruitment or internalization in several experimental systems. PD123319 is widely used as an experimental AT₂R antagonist, and the antagonist EMA401 (olodanrigan) has been evaluated in phase 2 trials for neuropathic pain. The selective oral AT₂R agonist buloxibutid (C21) is being evaluated in a phase 2b trial for idiopathic pulmonary fibrosis. No selective AT₂R agonist or antagonist is currently approved for therapeutic use. For more information on AT2 pharmacology please refer to the IUPHAR database. For further reading refer to:

de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72. PMID: 10977869.

Alexander W, Bernstein KE, Catt KJ, de Gasparo M, Dhanachandra Singh K, Eguchi S, Escher E, Goodfriend TL, Horiuchi M, Hunyady L, Husain A, Inagami T, Karnik S, Kemp J, Thomas WG, Timmermans PBMWM, Tirupula K, Unal H, Unger T, Vanderheyden P. Angiotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

The angiotensin II type 2 receptor (AT₂R), encoded by AGTR2 , is a class A G protein-coupled receptor activated by the endogenous peptides angiotensin II and angiotensin III. Its expression is... read more »
Close window
Angiotensin Receptor 2 Antibodies

The angiotensin II type 2 receptor (AT₂R), encoded by AGTR2, is a class A G protein-coupled receptor activated by the endogenous peptides angiotensin II and angiotensin III. Its expression is developmentally regulated and generally more restricted in adults, where it has been detected in the kidneys, adrenal glands, vasculature, and selected brain regions. AT₂R signaling is highly cell type-dependent and has been linked to protein phosphatase activation and the nitric oxide–cGMP pathway. In vascular and renal models, AT₂R activation can promote vasodilation and sodium excretion. Preclinical studies also suggest that it can limit inflammation and fibrosis. AT₂R shows little agonist-induced β-arrestin recruitment or internalization in several experimental systems. PD123319 is widely used as an experimental AT₂R antagonist, and the antagonist EMA401 (olodanrigan) has been evaluated in phase 2 trials for neuropathic pain. The selective oral AT₂R agonist buloxibutid (C21) is being evaluated in a phase 2b trial for idiopathic pulmonary fibrosis. No selective AT₂R agonist or antagonist is currently approved for therapeutic use. For more information on AT2 pharmacology please refer to the IUPHAR database. For further reading refer to:

de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72. PMID: 10977869.

Alexander W, Bernstein KE, Catt KJ, de Gasparo M, Dhanachandra Singh K, Eguchi S, Escher E, Goodfriend TL, Horiuchi M, Hunyady L, Husain A, Inagami T, Karnik S, Kemp J, Thomas WG, Timmermans PBMWM, Tirupula K, Unal H, Unger T, Vanderheyden P. Angiotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE. 2019; 2019(4).

Recently viewed