Melanin-Concentrating Hormone Receptor 2 (MCH2) Antibodies
The melanin-concentrating hormone receptor 1 (MCH1) is the receptor for a 19 amino-acids cyclic peptide. The highest expression of MCH1 is found in the brain: frontal cortex, amygdala and nucleus accumbens, but also in the arcuate nucleus and in the ventral medial hypothalamus. MCH1 seems to play a tole in appetite regulation and obesity. Knock out mice for MCH1 are leaner, even on high fat diet. Several antagonists at MCH1 showed antidepressant and anxiolytic activities. MCH1 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine338/threonine342 (pS338/pT342-MCH1) and threonine348/serine350 (pT348/pS350-MCH1). This nomenclature refers to the human MCH1 receptor but is identical in mice and rats. For more information on MCH1 receptor pharmacology please refer to the IUPHAR database. For further reading refer to:
Audinot V, Boutin JA, Lakaye B, Nahon JL, Saito Y. Melanin-concentrating hormone receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F37/2023.1.