GHRH Receptor Antibodies

The growth hormone-releasing hormone receptor (GHRHR), encoded by GHRHR, is a class B1 G protein-coupled receptor activated by hypothalamic growth hormone-releasing hormone (GHRH). It couples predominantly to Gs, stimulating adenylyl cyclase and increasing intracellular cAMP and protein kinase A activity. GHRHR is expressed primarily on anterior pituitary somatotrophs, where it promotes growth hormone synthesis and secretion. Its signaling supports somatotroph development and contributes to postnatal growth through the growth hormone–IGF-1 axis. Receptor expression and responsiveness are hormonally regulated, with sustained GHRH exposure capable of inducing desensitization. Loss-of-function variants in GHRHR cause autosomal recessive isolated growth hormone deficiency, often accompanied by anterior pituitary hypoplasia. Tesamorelin, a synthetic GHRH analogue, is approved in the United States to reduce excess abdominal fat in adults with HIV-associated lipodystrophy. Other GHRHR agonists and antagonists remain investigational, with several being studied in preclinical models of tissue repair and cancer. For more information on GHRH pharmacology please refer to the IUPHAR database. For further reading refer to:

Mayo KE, Miller LJ, Bataille D, Dalle S, Göke B, Thorens B, Drucker DJ. International Union of Pharmacology. XXXV. The glucagon receptor family. Pharmacol Rev. 2003 Mar;55(1):167-94. doi: 10.1124/pr.55.1.6. PMID: 12615957.

Bataille D, Chan SL, Delagrange P, Drucker DJ, Göke B, Hills R, Mayo KE, Miller LJ, Salvatori R, Thorens B. Glucagon receptor family in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1).