Premium Phosphosite-Specific 7TM Antibodies
Your Resource for GPCR Research
Select Your Country of Delivery below

Calcitonin Receptor-Like Receptor Antibodies

Close filters
No results were found for the filter!
NEW
CALCR [UMB26] (RM-IHC-Grade-Calcitonin Receptor-Like Receptor Antibody), Rabbit Monclonal
CALCR [UMB26] (RM-IHC-Grade-Calcitonin...
The non-phospho-CALCR receptor antibody is directed against the distal end of the carboxyl-terminal tail of human CALCR. It can be used to detect total CALCR receptors in Western blots independent of phosphorylation. The CALCR antibody...
$ 495.00 *
Details
NEW
Immunohistochemical identification of Calcitonin Receptor-Like Receptor in mouse brain
CALCR (IHC-grade) Calcitonin Receptor-Like...
The non-phospho-CALCR receptor antibody is directed against the distal end of the carboxyl-terminal tail of human CALCR. It can be used to detect total CALCR receptors in Western blots independent of phosphorylation. The CALCR antibody...
$ 375.00 *
Details
NEW
Validation of the Calcitonin Receptor-Like Receptor in transfected HEK293 cells
CALCR (non-phospho) Calcitonin Receptor-Like...
The non-phospho-CALCR receptor antibody is directed against the distal end of the carboxyl-terminal tail of human CALCR. It can be used to detect total CALCR receptors in Western blots independent of phosphorylation. The CALCR antibody...
$ 375.00 *
Details
NEW
Validation of the Calcitonin Receptor-Like Receptor in transfected HEK293 cells
CALCR (GP-non-phospho) Calcitonin Receptor-Like...
The non-phospho-CALCR receptor antibody is directed against the distal end of the carboxyl-terminal tail of human CALCR. It can be used to detect total CALCR receptors in Western blots independent of phosphorylation. The CALCR antibody...
$ 375.00 *
Details

The calcitonin receptor-like receptor (CLR), encoded by CALCRL, is a class B1 G protein-coupled receptor whose cell-surface expression and ligand selectivity depend on its association with receptor activity-modifying proteins (RAMPs). CLR pairs with RAMP1 to form the canonical calcitonin gene-related peptide (CGRP) receptor. Association with RAMP2 or RAMP3 forms the adrenomedullin AM₁ or AM₂ receptor, respectively. These complexes signal predominantly through Gs, stimulating adenylyl cyclase and increasing intracellular cAMP. CLR is expressed in vascular endothelial and smooth muscle cells, and the CLR–RAMP1 complex participates in trigeminovascular signaling relevant to migraine. Adrenomedullin signaling through CLR-containing receptors contributes to vascular tone, endothelial barrier integrity, and lymphatic development. Agonist stimulation can induce receptor internalization, and the associated RAMP can influence whether the complex recycles to the cell surface or is directed toward degradation. Erenumab, a monoclonal antibody targeting the canonical CGRP receptor, is approved for migraine prevention, while the small-molecule antagonist rimegepant is approved for both acute treatment and prevention of episodic migraine. For more information on CALCR receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Hay DL, Garelja ML, Poyner DR, Walker CS. Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25. Br J Pharmacol. 2018 Jan;175(1):3-17. doi: 10.1111/bph.14075. Epub 2017 Nov 28. PMID: 29059473; PMCID: PMC5740251.

Hay DL, Chen S, Lutz TA, Parkes DG, Roth JD. Amylin: Pharmacology, Physiology, and Clinical Potential. Pharmacol Rev. 2015 Jul;67(3):564-600. doi: 10.1124/pr.115.010629. PMID: 26071095.

Garelja ML, Hay D, Poyner DR, Walker CS. Calcitonin receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F11/2023.1.

The calcitonin receptor-like receptor (CLR), encoded by CALCRL , is a class B1 G protein-coupled receptor whose cell-surface expression and ligand selectivity depend on its association with... read more »
Close window
Calcitonin Receptor-Like Receptor Antibodies

The calcitonin receptor-like receptor (CLR), encoded by CALCRL, is a class B1 G protein-coupled receptor whose cell-surface expression and ligand selectivity depend on its association with receptor activity-modifying proteins (RAMPs). CLR pairs with RAMP1 to form the canonical calcitonin gene-related peptide (CGRP) receptor. Association with RAMP2 or RAMP3 forms the adrenomedullin AM₁ or AM₂ receptor, respectively. These complexes signal predominantly through Gs, stimulating adenylyl cyclase and increasing intracellular cAMP. CLR is expressed in vascular endothelial and smooth muscle cells, and the CLR–RAMP1 complex participates in trigeminovascular signaling relevant to migraine. Adrenomedullin signaling through CLR-containing receptors contributes to vascular tone, endothelial barrier integrity, and lymphatic development. Agonist stimulation can induce receptor internalization, and the associated RAMP can influence whether the complex recycles to the cell surface or is directed toward degradation. Erenumab, a monoclonal antibody targeting the canonical CGRP receptor, is approved for migraine prevention, while the small-molecule antagonist rimegepant is approved for both acute treatment and prevention of episodic migraine. For more information on CALCR receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Hay DL, Garelja ML, Poyner DR, Walker CS. Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25. Br J Pharmacol. 2018 Jan;175(1):3-17. doi: 10.1111/bph.14075. Epub 2017 Nov 28. PMID: 29059473; PMCID: PMC5740251.

Hay DL, Chen S, Lutz TA, Parkes DG, Roth JD. Amylin: Pharmacology, Physiology, and Clinical Potential. Pharmacol Rev. 2015 Jul;67(3):564-600. doi: 10.1124/pr.115.010629. PMID: 26071095.

Garelja ML, Hay D, Poyner DR, Walker CS. Calcitonin receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F11/2023.1.

Recently viewed