![pS373/pS374-V1B (phospho-Vasopressin Receptor 1B Antibody)](https://7tmantibodies.com/media/image/ac/67/30/pS373-pS374-V1B-F1_600x600.png)
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- Order number: 7TM0367A
- Content: 100 µl
- Host: Rabbit
Serine373/Serine374 (S373/S374) is major phosphorylation site of the Vasopressin Receptor 1B (V1B). The pS373/pS374-V1B antibody detects phosphorylation in response to agonists. S373/S374 phosphorylation is likely to be involved in efficient ligand sequestration by V1B.
Alternative Names | AVPR3, V1bR, antidiuretic hormone receptor 1b, vasopressin V3 receptor |
IUPHAR Target ID | 367 |
UniProt ID | P47901 |
Western Blot (WB) | 1:1000 |
Species Reactivity | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Immunogen | A synthetic phosphopeptide derived from human V1B around the phosphorylation site of Ser373/Ser374. |
Form | Liquid |
Purification | Antigen affinity chromatography |
Storage buffer | Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide |
Storage conditions | short-term 4°C, long-term -20°C |
Figure 1. Agonist-induced Serine373/Serine374 phosphorylation of the Vasopressin Receptor 1B. Upper panel, HEK293 cells stably expressing the Vasopressin receptor 1B (V1B) were either not exposed or exposed to 100 nM vasopressin for 30 minutes. Cells were lysed and immunoblotted with the anti-pS373/pS374-V1B antibody (7TM0367A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-V1B antibody to confirm equal loading of the gel.
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