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pS412-β1 (phospho-β1-Adrenoceptor Antibody)

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Agonist-induced Serine412 phosphorylation of the β1-Adrenoceptor
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  • 7TM0028B
  • 100 µl
  • Rabbit
Serine412 (S412) is a major phosphorylation site of the β1 adrenoceptor. The pS412-β1... more

Serine412 (S412) is a major phosphorylation site of the β1 adrenoceptor. The pS412-β1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S412 phosphorylation is primarily mediated by GRKs and is a key regulator of β1 desensitization, β-arrestin recruitment and internalization.

  Alternative Names β1, B1AR, ADRB1R, β1 Adrenergic... more

 

Alternative Names β1, B1AR, ADRB1R, β1 Adrenergic Receptor, β1-Adrenoceptor
IUPHAR Target ID  28
UniProt ID  P08588
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human β1 around the phosphorylation site of Ser412.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine412 phosphorylation of the β1-Adrenoceptor. Upper... more

Figure 1. Agonist-induced Serine412 phosphorylation of the β1-Adrenoceptor. Upper panel, HEK293 cells stably expressing the β1-Adrenoceptor (β1) were either not exposed or exposed to 10 µM of specific β1-adrenoceptor agonist Norepinephrene for 30 minutes. Cells were lysed and immunoblotted with the anti-pT404-β1 antibody (7TM0028B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-β1 antibody (7TM0028N) at a dilution of 1:1000 to confirm equal loading of the gel.




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