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- Order number: 7TM0056B
- Content: 100 µl
- Host: Rabbit
Serine429 (S429) is major phosphorylation site of the Cannabinoid Receptor 1 (CB1). The pS429-CB1 antibody detects phosphorylation in response to agonists. S429 phosphorylation is likely to be involved in efficient ligand sequestration by CB1.
Alternative Names | CB-R, Central Cannabinoid Receptor |
IUPHAR Target ID | 56 |
UniProt ID | PP21554 |
Western Blot (WB) | 1:1000 |
Species Reactivity | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Immunogen | A synthetic phosphopeptide derived from human CB1 around the phosphorylation site of Ser429. |
Form | Liquid |
Purification | Antigen affinity chromatography |
Storage buffer | Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide |
Storage conditions | short-term 4°C, long-term -20°C |
Figure 1. Agonist-induced Serine429 phosphorylation of the Cannabinoid Receptor 1. Upper panel, HEK293 cells stably expressing the CB1-Receptor (CB1) were either not exposed or exposed to 10 µM of CB1-Receptor agonists CP55940 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS429-CB1 antibody (7TM0056B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-CB1 antibody to confirm equal loading of the gel.
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