SST2 (GP-IHC-grade), Somatostatin Receptor 2 Antibody, Guinea Pig

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Preview: Immunohistochemical identification of Somatostatin Receptor 2 in human neuroendocrine tumor tissue

Preview: Western blot analysis of Somatostatin Receptor 2 in mouse tissues in vivo

Immunohistochemical identification of Somatostatin Receptor 2 in human neuroendocrine tumor tissue

Western blot analysis of Somatostatin Receptor 2 in mouse tissues in vivo

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Order number: 7TM0356N-ICGP
Content: 100 µl
Host: Rabbit

The SST2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of... more

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The SST2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Somatostatin Receptor 2. It detects selectively the canonical form of SST2 (also referred to as SST2A) and not the putative splice variant SST2B. In can be used to detect total SST2 receptors in Western blots independent of phosphorylation. The SST2 antibody can also be used to isolate and enrich SST2 receptors from tissue lysates. It also detects SST2 in cultured cells and tissue sections by immunohistochemistry.

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Alternative Names SST2, SSTR2, Somatostatin Receptor 2 IUPHAR... more

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Alternative Names	SST2, SSTR2, Somatostatin Receptor 2
IUPHAR Target ID	356
Uniprot ID	P30874 (human) P30875 (mouse) P30680 (rat)
Western Blot (WB)	1:1000
Immunohistochemistry (IHC)	1:100
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic peptide corresponding to residues 335–369 of human, mouse and rat SST2.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Immunohistochemical identification of Somatostatin Receptor 2 in human... more

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Figure 1. Immunohistochemical identification of Somatostatin Receptor 2 in human neuroendocrine tumor tissue. Sections were dewaxed, microwaved in citric acid, and incubated with anti-SST2 (Somatostatin Receptor 2) antibody (7TM0356N-ICGP) at a dilution of 1:100. Sections were then sequentially treated with biotinylated anti-rabbit IgG and avidin-biotin solution. Sections were then developed in 3,3-diaminobenzidine (DAB)-glucose oxidase and lightly counterstained with hematoxylin. Note, SST2 receptors were uniformly detected at the plasma membrane of nearly all tumor cells.

Figure 2. Western blot analysis of Somatostatin Receptor 2 in mouse tissues in vivo. Tissues from wildtype mice were dissected, homogenated and immunoblotted using guinea pig anti-SST2 (Somatostatin-Receptor 2) antibody (7TM0356N-ICGP) at a dilution of 1:1000. Note, SST2 receptors were predominatly detected in brain and pancreas.