pT346-FPR2 (phospho-Formylpeptide Receptor 2 Antibody)

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Agonist-induced Threonine346 phosphorylation of FPR2 Receptor

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Order number: 7TM0223B
Content: 100 µl
Host: Rabbit

Threonine346 (T346) is a major phosphorylation site of the FPR2 receptor. The pT346-FPR2... more

Threonine346 (T346) is a major phosphorylation site of the FPR2 receptor. The pT346-FPR2 antibody detects phosphorylation in response to high-efficacy agonists. T346 phosphorylation is a key regulator of FPR2 desensitization, β-arrestin recruitment and internalization.

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Alternative Names ALXR, FPRL1, FPRH2, Formyl-peptide Receptor-like 1,... more

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Alternative Names	ALXR, FPRL1, FPRH2, Formyl-peptide Receptor-like 1, Formyl-peptide Receptor 2
IUPHAR Target ID	223
UniProt ID	P25090
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human FPR2 around the phosphorylation site Thr346.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Threonine346 phosphorylation of FPR2 Receptor. Upper panel, HEK293... more

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Figure 1. Agonist-induced Threonine346 phosphorylation of FPR2 Receptor. Upper panel, HEK293 cells stably expressing the FPR2-Receptor (FPR2) were either not exposed or exposed to 1 µM of specific FPR-Receptor agonist fMet-Leu-Phe for 30 minutes. Cells were lysed and immunoblotted with the anti-pT346-FPR2 antibody (7TM0223B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-FPR2 antibody to confirm equal loading of the gel.

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