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pS343/pT345-CMKLR2 (phospho-Chemerin Receptor 2 Antibody)

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Agonist-induced Serine343/Threonine345 phosphorylation of Chemerin Receptor 2
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  • 7TM0082C
  • 100 µl
  • Rabbit
Serine343/Threonine345 (S343/T345) is a major phosphorylation site of the Chemerin receptor 2... more

Serine343/Threonine345 (S343/T345) is a major phosphorylation site of the Chemerin receptor 2 (CMKLR2). The pS343/pT345-CMKLR2 antibody detects phosphorylation in response to high-efficacy agonists. S343/T345 phosphorylation is a key regulator of CMKLR2 desensitization, β-arrestin recruitment and internalization.

  Alternative Names CMKLR2, Chemerin 2 IUPHAR Target ID   82... more

 

Alternative Names CMKLR2, Chemerin2
IUPHAR Target ID  82
UniProt ID  P46091
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human CMKLR2 around the phosphorylation site Ser343/Thr345.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine343/Threonine345 phosphorylation of Chemerin Receptor 2.... more

Figure 1. Agonist-induced Serine343/Threonine345 phosphorylation of Chemerin Receptor 2. Upper panel, HEK293 cells stably expressing the Chemerin Receptor 2 (CMKLR2) were either not exposed or exposed to 100 nM Chemerin for 30 minutes. Cells were lysed and immunoblotted with the anti-pS343/pT345-CMKLR2 antibody (7TM0082C) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-CMKLR2 antibody to confirm equal loading of the gel.

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