pS445-GCGR (phospho-Glucagon Receptor Antibody)

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Agonist-induced Serine445 phosphorylation of Glucagon Receptor

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Order number: 7TM0251A
Content: 100 µl
Host: Rabbit

Serine445 (S445) is major phosphorylation site of human GCGR receptor. The pS445-GCGR... more

Serine445 (S445) is major phosphorylation site of human GCGR receptor. The pS445-GCGR antibody detects phosphorylation in response to agonists. S445 phosphorylation is likely to be involved in efficient ligand sequestration by the Glucagon Receptor.

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Alternative Names GGR IUPHAR Target ID 251... more

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Alternative Names	GGR
IUPHAR Target ID	251
UniProt ID	P47871
Western Blot (WB)	1:1000
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human GCGR around the phosphorylation site of Ser445.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine445 phosphorylation of Glucagon Receptor. Upper panel,... more

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Figure 1. Agonist-induced Serine445 phosphorylation of Glucagon Receptor. Upper panel, HEK293 cells stably expressing the glucagon receptor (GCGR) and transiently GRK2 (Ratio GCGR receptor:GRK2 = 10:1) were preincubated with serum-free media. After 2 hours cells were either not exposed or exposed to 100 nM of Glucagon for 30 minutes. Cells were lysed and immunoblotted with the anti-pS445-GCGR antibody (7TM0251A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-GCGR antibody (7TM0251N) to confirm equal loading of the gel.

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