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Orphan Receptor Antibodies

The sequencing of the human genome has allowed NC-IUPHAR to catalog all of the human gene sequences potentially encoding GPCRs, excluding sensory receptors. In addition to established transmitter systems, the classification in the Guide to PHARMACOLOGY also includes ‘orphan’ GPCRs where the endogenous ligand(s) is not known. Considerable progress has been made in screening artificially expressed receptors to identify the cognate endogenous ligand.

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Agonist-induced Serine371 phosphorylation of GPR88-Receptor.
pS371-GPR88 (phospho-GPR88 Antibody)
Serine371 (S371) is a major phosphorylation site of the human GPR88 receptor. The pS371-GPR88 antibody detects phosphorylation in response to high-efficacy agonists. S371 phosphorylation is a key regulator of human GPR88 desensitization,...
$ 375.00 *
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Agonist-induced Threonine365/Serine371/Threonine377 phosphorylation of GPR88-Receptor
pT365/pS371/pT377-GPR88 (phospho-GPR88 Antibody)
Threonine365/Serine371/Threonine377 (T365/S371/T377) is a major phosphorylation site of the human GPR88 receptor. The pT365/pS371/pT377-GPR88 antibody detects phosphorylation in response to high-efficacy agonists. T365/S371/T377...
$ 375.00 *
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Validation of the G Protein-coupled Receptor 17 in transfected HEK293 cells
GPR17 (GP-non-phospho), G Protein-coupled...
The non-phospho-GPR17 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human GPR17. It can be used to detect total GPR17 receptors in Western blots independent of phosphorylation. The...
$ 375.00 *
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Validation of the GPR37 Receptor in transfected HEK293 cells
GPR37 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR37 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR37. It can be used to detect total GPR37 receptors in Western blots independent of phosphorylation. The GPR37 antibody...
$ 375.00 *
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Validation of the GPR45 Receptor in transfected HEK293 cells.
GPR45 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR45 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR45. It can be used to detect total GPR45 receptors in Western blots independent of phosphorylation. The GPR45 antibody...
$ 375.00 *
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Validation of the GPR135 Receptor in transfected HEK293 cells.
GPR135 (non-phospho), G protein-coupled...
The non-phospho-GPR135 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR135. It can be used to detect total GPR135 receptors in Western blots independent of phosphorylation. The GPR135...
$ 375.00 *
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Validation of the GPR142 Receptor in transfected HEK293 cells.
GPR142 (non-phospho), G protein-coupled...
The non-phospho-GPR142 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR142. It can be used to detect total GPR142 receptors in Western blots independent of phosphorylation. The GPR142...
$ 375.00 *
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Validation of the GPR161 Receptor in transfected HEK293 cells
GPR161 (GP-non-phospho), G protein-coupled...
The non-phospho-GPR161 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR161. It can be used to detect total GPR161 receptors in Western blots independent of phosphorylation. The GPR161...
$ 375.00 *
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Validation of the GPR151 Receptor in transfected HEK293 cells
GPR151 (non-phospho), G protein-coupled...
The non-phospho-GPR151 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR151. It can be used to detect total GPR151 receptors in Western blots independent of phosphorylation. The GPR151...
$ 375.00 *
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Validation of the GPR152 Receptor in transfected HEK293 cells.
GPR152 (non-phospho), G protein-coupled...
The non-phospho-GPR152 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR152. It can be used to detect total GPR152 receptors in Western blots independent of phosphorylation. The GPR152...
$ 375.00 *
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Validation of the GPR156 Receptor in transfected HEK293 cells.
GPR156 (non-phospho), G protein-coupled...
The non-phospho-GPR156 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR156. It can be used to detect total GPR156 receptors in Western blots independent of phosphorylation. The GPR156...
$ 375.00 *
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Validation of the ADGRD1/GPR133 Receptor in transfected HEK293 cells
ADGRD1/GPR133 (non-phospho), Adhesion Receptor...
The non-phospho-ADGRD1/GPR133 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human ADGRD1/GPR133. It can be used to detect total ADGRD1/GPR133 receptors in Western blots independent of...
$ 375.00 *
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Validation of the ADGRD1/GPR133 Receptor in transfected HEK293 cells
ADGRD1/GPR133 (GP-non-phospho), Adhesion...
The non-phospho-ADGRD1/GPR133 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human ADGRD1/GPR133. It can be used to detect total ADGRD1/GPR133 receptors in Western blots independent of...
$ 375.00 *
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Validation of the GPR153 Receptor in transfected HEK293 cells.
GPR153 (non-phospho), G protein-coupled...
The non-phospho-GPR153 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR153. It can be used to detect total GPR153 receptors in Western blots independent of phosphorylation. The GPR153...
$ 375.00 *
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Validation of the mouse GPR62 Receptor in transfected HEK293 cells.
mGPR62 (non-phospho), Mouse G protein-coupled...
The non-phospho-mGPR62 receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse GPR62. It can be used to detect total GPR62 receptors in Western blots independent of phosphorylation. The GPR62 antibody...
$ 375.00 *
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Validation of the MRGPRX2 Receptor in transfected HEK293 cells
MRGPRX2 (non-phospho), MRGPRX2 Mas-related...
The non-phospho-MRGPRX2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human MRGPRX2. It can be used to detect total MRGPRX2 receptors in Western blots independent of phosphorylation. The MRGPRX2...
$ 375.00 *
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For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

For more information on orphan receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE,... read more »
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Orphan Receptor Antibodies

For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

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