pS412/pS413-PAR1 (phospho-Proteinase-Activated Receptor 1 Antibody)

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Agonist-induced Serine412/Serine413 phosphorylation of the Protease-Activated Receptor

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Order number: 7TM0347A
Content: 100 µl
Host: Rabbit

Serine412/Serine413 (S412/S413) is major phosphorylation site of the Proteinase-Activated... more

Serine412/Serine413 (S412/S413) is major phosphorylation site of the Proteinase-Activated Receptor 1 (PAR1). The pS412/pS413-PAR1 antibody detects phosphorylation in response to agonists. S412/S413 phosphorylation is likely to be involved in efficient ligand sequestration by PAR1.

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Alternative Names Coagulation Factor II Receptor, Protease-Activated... more

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Alternative Names	Coagulation Factor II Receptor, Protease-Activated Receptor 1
IUPHAR Target ID	347
UniProt ID	P25116
Western Blot (WB)	1:1000
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human PAR1 around the phosphorylation site of Ser412/Ser413.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine412/Serine413 phosphorylation of the Protease-Activated... more

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Figure 1. Agonist-induced Serine412/Serine413 phosphorylation of the Protease-Activated Receptor 1. Upper panel, HEK293 cells stably expressing the Proteinase-activated receptor 1 (PAR1) were either not exposed or exposed to 100 nM TFLLRNH₂ for 30 minutes. Cells were lysed and immunoblotted with the anti-pS412/pS413-PAR1 antibody (7TM0347A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-PAR1 antibody (7TM0347N) to confirm equal loading of the gel.

Be the first to analyze the PAR1 phosphorylation using our anti-pS412/pS413-PAR1... more

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Be the first to analyze the PAR1 phosphorylation using our anti-pS412/pS413-PAR1 antibody and let us know.

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