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pS351/pS353-S1P1 (phospho-Sphingosine 1-Phosphate Receptor 1 Antibody)

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Agonist-induced Serine351/Serine353 phosphorylation of the Sphingosine 1-Phosphate Receptor 1
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  • 7TM0275A
  • 100 µl
  • Rabbit
Serine351/Serine353 (S351/S353) is major phosphorylation site of the Sphingosine... more

Serine351/Serine353 (S351/S353) is major phosphorylation site of the Sphingosine 1-Phosphate Receptor 1 (S1P1). The pS351/pS353-S1P1 antibody detects phosphorylation in response to agonists. S351/S353 phosphorylation is likely to be involved in efficient ligand sequestration by S1P1.

  Alternative Names CD363, Edg1, endothelial differentiation G... more

 

Alternative Names CD363, Edg1, endothelial differentiation G protein-coupled receptor 1 Receptor
IUPHAR Target ID  275
UniProt ID  P21453
Western Blot (WB)  1:1000
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human S1P1 around the phosphorylation site of Ser351/Ser353.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine351/Serine353 phosphorylation of the Sphingosine 1-Phosphate... more

Figure 1. Agonist-induced Serine351/Serine353 phosphorylation of the Sphingosine 1-Phosphate Receptor 1. Upper panel, HEK293 cells stably expressing the S1P1-Receptor (S1P1) were either not exposed or exposed to 1 µM of S1P1-Receptor agonists S1P for 30 minutes. Cells were lysed and immunoblotted with the anti-pS351/pS353-S1P1 antibody (7TM00275A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-S1P1 antibody to confirm equal loading of the gel.

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