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pS716/pT717-TSHR (phospho-Thyrotropin Receptor Antibody)

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Agonist-induced Serine716/Threonine717 phosphorylation of the Thyrotropin Receptor
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  • 7TM0255A
  • 100 µl
  • Rabbit
Serine716/Threonine717 (S716/T717) is major phosphorylation site of the Thyrotropin Receptor... more

Serine716/Threonine717 (S716/T717) is major phosphorylation site of the Thyrotropin Receptor (TSHR). The pS716/pT717-TSHR antibody detects phosphorylation in response to agonists. S716/T717 phosphorylation is likely to be involved in efficient ligand sequestration by TSHR.

  Alternative Names LGR3 IUPHAR Target ID   255... more

 

Alternative Names LGR3
IUPHAR Target ID  255
UniProt ID  P16473
Western Blot (WB)  1:1000
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human TSHR around the phosphorylation site of Ser716/Thr717.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine716/Threonine717 phosphorylation of the Thyrotropin Receptor.... more

Figure 1. Agonist-induced Serine716/Threonine717 phosphorylation of the Thyrotropin Receptor. Upper panel, HEK293 cells stably expressing the Thyrotropin receptor (TSHR) were either not exposed or exposed to 100 nM TSH for 30 minutes. Cells were lysed and immunoblotted with the anti-pS716/pT717-TSHR antibody (7TM0255A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-TSHR antibody to confirm equal loading of the gel.

 

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Be the first to analyze the TSHR phosphorylation using our anti-pS716/pT717-TSHR antibody and let us know.

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