SST1 (IHC-grade), Somatostatin Receptor 1 Antibody

SST1 (IHC-grade), Somatostatin Receptor 1 Antibody

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Order number: 7TM0355N-IC
Content: 100 µl
Host: Rabbit

The SST1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of... more

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The SST1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Somatostatin Receptor 1. It can be used to detect total SST1 receptors in Western blots independent of phosphorylation. The SST1 antibody can also be used to isolate and enrich SST1 receptors from cell and tissue lysates. It also detects SST1 in cultured cells and tissue sections by immunohistochemistry.

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Alternative Names SST1, SSTR1, Somatostatin Receptor 1 IUPHAR... more

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Alternative Names	SST1, SSTR1, Somatostatin Receptor 1
IUPHAR Target ID	355
UniProt ID	P30872
Western Blot (WB)	1:1000
Immunohistochemistry (IHC)	1:100
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic peptide with sequence ENLESGGVFRNGTCTSRITTL corresponds to amino acids 371-391 of human SST1
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Immunohistochemical identification of Somatostatin Receptor 1 in human pituitary.... more

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Figure 1. Immunohistochemical identification of Somatostatin Receptor 1 in human pituitary. Sections were dewaxed, microwaved in citric acid, and incubated with anti-SST1 (Somatostatin Receptor 1) antibody (7TM0355N-IC) at a dilution of 1:100. Sections were then sequentially treated with biotinylated anti-rabbit IgG and avidin-biotin solution. Sections were then developed in 3,3-diaminobenzidine (DAB)-glucose oxidase and lightly counterstained with hematoxylin. Note, SST1 receptors were detected in distinct cell population in human anterior pituitary.

Figure 2. Validation of the Somatostatin Receptor 1 in transfected HEK293 cells. Native HEK293 cells (MOCK) or HEK293 cells stably expressing the Somatostatin Receptor 1 (SST1) were lysed and immunoblotted with the phosphorylation-independent anti-SST1 antibody (7TM0355N) at a dilution of 1:1000.

Schulz S, Pauli SU, Schulz S, Händel M, Dietzmann K, Firsching R, Höllt V. Immunohistochemical... more

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Schulz S, Pauli SU, Schulz S, Händel M, Dietzmann K, Firsching R, Höllt V. Immunohistochemical determination of five somatostatin receptors in meningioma reveals frequent overexpression of somatostatin receptor subtype sst2A. Clin Cancer Res. 2000 May;6(5):1865-74. PubMed PMID: 10815909.

Lupp A, Nagel F, Schulz S. Reevaluation of sst₁ somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-7. Regul Pept. 2013 May 10;183:1-6. doi: 10.1016/j.regpep.2013.02.001. Epub 2013 Mar 4. PubMed PMID: 23466804.

Casar-Borota O, Heck A, Schulz S, Nesland JM, Ramm-Pettersen J, Lekva T, Alafuzoff I, Bollerslev J. Expression of SSTR2a, but not of SSTRs 1, 3, or 5 in somatotroph adenomas assessed by monoclonal antibodies was reduced by octreotide and correlated with the acute and long-term effects of octreotide. J Clin Endocrinol Metab. 2013 Nov;98(11):E1730-9. doi: 10.1210/jc.2013-2145. Epub 2013 Oct 3. PubMed PMID: 24092823.