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pS425-CB1 (phospho-Cannabinoid Receptor 1 Antibody)

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Agonist-induced Serine425 phosphorylation of the Cannabinoid Receptor 1
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  • 7TM0056A
  • 100 µl
  • Rabbit
Serine425 (S425) is major phosphorylation site of the Cannabinoid Receptor 1 (CB1). The... more

Serine425 (S425) is major phosphorylation site of the Cannabinoid Receptor 1 (CB1). The pS425-CB1 antibody detects phosphorylation in response to agonists. S425 phosphorylation is likely to be involved in efficient ligand sequestration by CB1.

  Alternative Names CB-R, Central Cannabinoid Receptor IUPHAR Target... more

 

Alternative Names CB-R, Central Cannabinoid Receptor
IUPHAR Target ID  56
UniProt ID  P21554
Western Blot (WB)  1:1000
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human CB1 around the phosphorylation site of Ser425.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine425 phosphorylation of the Cannabinoid Receptor 1. Upper... more

Figure 1. Agonist-induced Serine425 phosphorylation of the Cannabinoid Receptor 1. Upper panel, HEK293 cells stably expressing the CB1-Receptor (CB1) were either not exposed or exposed to 10 µM of CB1-Receptor agonists CP55940 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS425-CB1 antibody (7TM0056A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-CB1 antibody to confirm equal loading of the gel.

Fritzwanker S, Nagel F, Kliewer A, Stammer V, Schulz S. In situ visualization of opioid and... more

Fritzwanker S, Nagel F, Kliewer A, Stammer V, Schulz S. In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies. Commun Biol. 2023 Apr 15;6(1):419. doi: 10.1038/s42003-023-04786-2. PMID: 37061609; PMCID: PMC10105690.

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