pS345/pS346-CMKLR1 (phospho-Chemerin Receptor 1 Antibody)

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Agonist-induced Serine345/Serine346 phosphorylation of Chemerin Receptor 1

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Order number: 7TM0079A
Content: 100 µl
Host: Rabbit

Serine345/Serine346 (S345/S346) is a major phosphorylation site of the Chemerin receptor 1... more

Serine345/Serine346 (S345/S346) is a major phosphorylation site of the Chemerin receptor 1 (CMKLR1). The pS345/pS346-CMKLR1 antibody detects phosphorylation in response to high-efficacy agonists. S345/S346 phosphorylation is a key regulator of CMKLR1 desensitization, β-arrestin recruitment and internalization.

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Alternative Names CMKLR1, Chemerin 1 , Chemokine Receptor-like 1, Resolvin... more

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Alternative Names	CMKLR1, Chemerin₁, Chemokine Receptor-like 1, Resolvin E1 Receptor, TIG2 Receptor
IUPHAR Target ID	79
UniProt ID	Q99788
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human CMKLR1 around the phosphorylation site Ser345/Ser346.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine345/Serine346 phosphorylation of Chemerin Receptor 1. Upper... more

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Figure 1. Agonist-induced Serine345/Serine346 phosphorylation of Chemerin Receptor 1. Upper panel, HEK293 cells stably expressing the Chemerin Receptor 1 (CMKLR1) were either not exposed or exposed to 100 nM of Chemerin for 30 minutes. Cells were lysed and immunoblotted with the anti-pS345/pS346-CMKLR1 antibody (7TM0079A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-CMKLR1 antibody to confirm equal loading of the gel.

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