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pS345/pS346-CMKLR1 (phospho-Chemerin Receptor 1 Antibody)

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Agonist-induced Serine345/Serine346 phosphorylation of Chemerin Receptor 1
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  • 7TM0079A
  • 100 µl
  • Rabbit
Serine345/Serine346 (S345/S346) is a major phosphorylation site of the Chemerin receptor 1... more

Serine345/Serine346 (S345/S346) is a major phosphorylation site of the Chemerin receptor 1 (CMKLR1). The pS345/pS346-CMKLR1 antibody detects phosphorylation in response to high-efficacy agonists. S345/S346 phosphorylation is a key regulator of CMKLR1 desensitization, β-arrestin recruitment and internalization.

  Alternative Names CMKLR1, Chemerin 1 , Chemokine Receptor-like 1, Resolvin... more

 

Alternative Names CMKLR1, Chemerin1, Chemokine Receptor-like 1, Resolvin E1 Receptor, TIG2 Receptor
IUPHAR Target ID  79
UniProt ID  Q99788
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human CMKLR1 around the phosphorylation site Ser345/Ser346.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine345/Serine346 phosphorylation of Chemerin Receptor 1. Upper... more

Figure 1. Agonist-induced Serine345/Serine346 phosphorylation of Chemerin Receptor 1. Upper panel, HEK293 cells stably expressing the Chemerin Receptor 1 (CMKLR1) were either not exposed or exposed to 100 nM of Chemerin for 30 minutes. Cells were lysed and immunoblotted with the anti-pS345/pS346-CMKLR1 antibody (7TM0079A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-CMKLR1 antibody to confirm equal loading of the gel.

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