pS357/pS358-CMKLR1 (phospho-Chemerin Receptor 1 Antibody)

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Agonist-induced Serine357/Serine358 phosphorylation of Chemerin Receptor 1.

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Order number: 7TM0079C
Content: 100 µl
Host: Rabbit

Serine357/Serine358 (S357/S358) is a major phosphorylation site of the Chemerin receptor 1... more

Serine357/Serine358 (S357/S358) is a major phosphorylation site of the Chemerin receptor 1 (CMKLR1). The pS357/pS358-CMKLR1 antibody detects phosphorylation in response to high-efficacy agonists. S357/S358 phosphorylation is a key regulator of CMKLR1 desensitization, β-arrestin recruitment and internalization.

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Alternative Names CMKLR1, Chemerin 1 , Chemokine Receptor-like 1, Resolvin... more

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Alternative Names	CMKLR1, Chemerin₁, Chemokine Receptor-like 1, Resolvin E1 Receptor, TIG2 Receptor
IUPHAR Target ID	79
UniProt ID	Q99788
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human CMKLR1 around the phosphorylation site Ser357/Ser358.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine357/Serine358 phosphorylation of Chemerin Receptor 1. Upper... more

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Figure 1. Agonist-induced Serine357/Serine358 phosphorylation of Chemerin Receptor 1. Upper panel, HEK293 cells stably expressing the Chemerin Receptor (CMKLR1) were either not exposed or exposed to 100 nM Chemerin for 30 minutes. Cells were lysed and immunoblotted with the anti-pS357/pS358-CMKLR1 antibody (7TM0079C) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-CMKLR1 antibody to confirm equal loading of the gel.