![Agonist-induced Serine358/Threonine360/Serine361 phosphorylation of the CXC Chemokine Receptor 3](https://7tmantibodies.com/media/image/42/2e/5d/pS358-pT360-pS361-CXCR3-F14YeaLTaowoPty_600x600.png)
Prices plus VAT plus shipping costs
Ready to ship today,
Delivery time appr. 5-8 days
- Order number: 7TM0070A
- Content: 100 µl
- Host: Rabbit
Serine358/Threonine360/Serine361 (S358/T360/S361) are a major phosphorylation sites of the CXCR3 receptor. The pS358/pT360/pS361-CXCR3 detects phosphorylation in response to high- and low-efficacy agonists. S358/T360/S361 phosphorylation is a key regulator of CXCR3 desensitization, β-arrestin recruitment and internalization.
Alternative Names | CXC-R3, Chemokine (C-X-C motif) Receptor 3, IP-10 Receptor |
IUPHAR Target ID | 70 |
UniProt ID | P49682 |
Western Blot (WB) | 1:1000 |
Immunocytochemistry (ICC) | - |
Species Reactivity | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Immunogen | A synthetic phosphopeptide derived from human CXCR3 around the phosphorylation site of Ser358/Thr360/Ser361. |
Form | Liquid |
Purification | Antigen affinity chromatography |
Storage buffer | Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide |
Storage conditions | short-term 4°C, long-term -20°C |
Figure 1. Agonist-induced Serine358/Threonine360/Serine361 phosphorylation of the CXC Chemokine Receptor 3. Upper panel, HEK293 cells stably expressing the CXC Chemokine Receptor 3 (CXCR3) were either not exposed or exposed to 100 nM specific CXC Chemokine receptor 3 agonist CXCL11 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS358/pT360/pS361-CXCR3 antibody (7TM0070A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent CXCR3 antibody (7TM0070N) at a dilution of 1:1000 to confirm equal loading of the gel.
Be the first to decipher the CXCR2 phosphorylation barcode and let us know.