pS358/pT360/pS361-CXCR3 (phospho-CXC Chemokine Receptor 3 Antibody)

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Agonist-induced Serine358/Threonine360/Serine361 phosphorylation of the CXC Chemokine Receptor 3

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Order number: 7TM0070A
Content: 100 µl
Host: Rabbit

Serine358/Threonine360/Serine361 (S358/T360/S361) are a major phosphorylation sites of the CXCR3... more

Serine358/Threonine360/Serine361 (S358/T360/S361) are a major phosphorylation sites of the CXCR3 receptor. The pS358/pT360/pS361-CXCR3 detects phosphorylation in response to high- and low-efficacy agonists. S358/T360/S361 phosphorylation is a key regulator of CXCR3 desensitization, β-arrestin recruitment and internalization.

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Alternative Names CXC-R3, Chemokine (C-X-C motif) Receptor 3, IP-10... more

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Alternative Names	CXC-R3, Chemokine (C-X-C motif) Receptor 3, IP-10 Receptor
IUPHAR Target ID	70
UniProt ID	P49682
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human CXCR3 around the phosphorylation site of Ser358/Thr360/Ser361.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine358/Threonine360/Serine361 phosphorylation of the CXC... more

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Figure 1. Agonist-induced Serine358/Threonine360/Serine361 phosphorylation of the CXC Chemokine Receptor 3. Upper panel, HEK293 cells stably expressing the CXC Chemokine Receptor 3 (CXCR3) were either not exposed or exposed to 100 nM specific CXC Chemokine receptor 3 agonist CXCL11 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS358/pT360/pS361-CXCR3 antibody (7TM0070A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent CXCR3 antibody (7TM0070N) at a dilution of 1:1000 to confirm equal loading of the gel.

Be the first to decipher the CXCR2 phosphorylation barcode and let us know. more

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Be the first to decipher the CXCR2 phosphorylation barcode and let us know.

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