pS435/pS436-ETB (phospho-Endothelin Receptor B Antibody)

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Agonist-induced Serine435/Serine436 phosphorylation of the Endothelin Receptor B

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Order number: 7TM0220A
Content: 100 µl
Host: Rabbit

Serine435/Serine436 (S435/S436) is major phosphorylation site of the Endothelin Receptor B... more

Serine435/Serine436 (S435/S436) is major phosphorylation site of the Endothelin Receptor B (ETB). The pS435/pS436-ETB antibody detects phosphorylation in response to agonists. S435/S436 phosphorylation is likely to be involved in efficient ligand sequestration by ETB.

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Alternative Names HSCR, ET-RB, EDNRB IUPHAR Target ID 220... more

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Alternative Names	HSCR, ET-RB, EDNRB
IUPHAR Target ID	220
UniProt ID	P24530
Western Blot (WB)	1:1000
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human ETB around the phosphorylation site of Ser435/Ser436.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine435/Serine436 phosphorylation of the Endothelin Receptor B.... more

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Figure 1. Agonist-induced Serine435/Serine436 phosphorylation of the Endothelin Receptor B. Upper panel, HEK293 cells stably expressing the Endothelin receptor B (ETB) were either not exposed or exposed to 100 nM Endothelin 1 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS435/pS436-ETB antibody (7TM0220A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-ETB antibody to confirm equal loading of the gel.

Be the first to analyze the ETB phosphorylation using our anti-pS435/pS436-ETB... more

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Be the first to analyze the ETB phosphorylation using our anti-pS435/pS436-ETB antibody and let us know.

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