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Orphan Receptor Antibodies

The sequencing of the human genome has allowed NC-IUPHAR to catalog all of the human gene sequences potentially encoding GPCRs, excluding sensory receptors. In addition to established transmitter systems, the classification in the Guide to PHARMACOLOGY also includes ‘orphan’ GPCRs where the endogenous ligand(s) is not known. Considerable progress has been made in screening artificially expressed receptors to identify the cognate endogenous ligand.

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Validation of the GPR119 Receptor in transfected HEK293 cells
GPR119 (non-phospho), G protein-coupled...
The non-phospho-GPR119 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR119. It can be used to detect total GPR119 receptors in Western blots independent of phosphorylation. The GPR119...
$ 375.00 *
NEW
Validation of the GPR62 Receptor in transfected HEK293 cells
GPR62 (non-phospho), G protein-coupled...
The non-phospho-GPR62 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR62. It can be used to detect total GPR62 receptors in Western blots independent of phosphorylation. The GPR62 antibody...
$ 375.00 *
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Validation of the GPR97/ADGR3G Receptor in transfected HEK293 cells
ADGRG3/GPR97 (non-phospho), Adhesion Receptor...
The non-phospho-ADGRG3/GPR97 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human ADGRG3/GPR97. It can be used to detect total ADGRG3/GPR97 receptors in Western blots independent of phosphorylation....
$ 375.00 *
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Agonist-induced Serine300/Serine303 phosphorylation of GPR35 Receptor.
pS300/pS303-hGPR35 (phospho-human GPR35 Antibody)
Serine300/Serine303 (S300/S303) is a major phosphorylation site of the human GPR35 receptor. The pS300/pS303-hGPR35 antibody detects phosphorylation in response to high-efficacy agonists. S300/S303 phosphorylation is a key regulator of...
$ 350.00 *
Citations
NEW
 Agonist-induced Serine298/Serine301 phosphorylation of mouse GPR35 Receptor
pS298/pS301-mGPR35 (phospho-mouse GPR35 Antibody)
Serine298/Serine301 (S298/S301) is a major phosphorylation site of the mouse GPR35 receptor. The pS298/pS301-mGPR35 antibody detects phosphorylation in response to high-efficacy agonists. S298/S301 phosphorylation is a key regulator of...
$ 375.00 *
NEW
Validation of the GPR132 Receptor in transfected HEK293 cells
GPR132 (non-phospho), G protein-coupled...
The non-phospho-GPR132 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR132. It can be used to detect total GPR132 receptors in Western blots independent of phosphorylation. The GPR132...
$ 375.00 *
NEW
Validation of the GPR88 Receptor in transfected HEK293 cells
GPR88 (non-phospho), G protein-coupled...
The non-phospho-GPR88 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR88. It can be used to detect total GPR88 receptors in Western blots independent of phosphorylation. The GPR88 antibody...
$ 375.00 *
NEW
Validation of the GPR52 Receptor in transfected HEK293 cells
GPR52 (non-phospho), G protein-coupled...
The non-phospho-GPR52 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR52. It can be used to detect total GPR52 receptors in Western blots independent of phosphorylation. The GPR52 antibody...
$ 375.00 *
Citations
NEW
 Detection of non-phosphorylated human GPR35 Receptor
GPR35 (non-phospho), G Protein-coupled Receptor...
The non-phospho-GPR35 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human GPR35. It can be used to detect total GPR35 receptors in Western blots independent of phosphorylation. The...
$ 375.00 *
NEW
 Validation of the SUCNR1 Receptor in transfected HEK293 cells
SUCNR1/GPR91 (non-phospho), Succinate Receptor...
The non-phospho-SUCNR1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human SUCNR1. It can be used to detect total SUCNR1 receptors in Western blots independent of phosphorylation. The SUCNR1...
$ 375.00 *
NEW
Immunohistochemical identification of MRGPRX2 Receptor in Pancreas
MRGPRX2 (GP-IHC-grade), MRGPRX2 Mas-related...
The non-phospho-MRGPRX2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human MRGPRX2. It can be used to detect total MRGPRX2 receptors in Western blots independent of phosphorylation. The MRGPRX2...
$ 375.00 *
NEW
Agonist-induced Serine351/Threonine356 phosphorylation of the G-protein coupled Receptor 17
pS351/pT356-GPR17 (phospho-GPR17 Antibody)
Serine351/Threonine356 (S351/T356) is a major phosphorylation site of the human GPR17 receptor. The pS351/pT356-GPR17 antibody detects phosphorylation in response to high-efficacy agonists. S351/T356 phosphorylation is a key regulator of...
$ 375.00 *
NEW
Validation of the GPR18 Receptor in transfected HEK293 cells.
GPR18 (non-phospho), G protein-coupled...
The non-phospho-GPR18 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR18. It can be used to detect total GPR18 receptors in Western blots independent of phosphorylation. The GPR18 antibody...
$ 375.00 *
NEW
Validation of the GPR82 Receptor in transfected HEK293 cells
GPR82 (non-phospho), G protein-coupled...
The non-phospho-GPR82 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR82. It can be used to detect total GPR82 receptors in Western blots independent of phosphorylation. The GPR82 antibody...
$ 375.00 *
NEW
Validation of the GPR65 Receptor in transfected HEK293 cells
GPR65 (non-phospho), G protein-coupled...
The non-phospho-GPR65 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR65. It can be used to detect total GPR65 receptors in Western blots independent of phosphorylation. The GPR65 antibody...
$ 375.00 *
NEW
Validation of the GPR61 Receptor in transfected HEK293 cells
GPR61 (non-phospho), G protein-coupled...
The non-phospho-GPR61 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR61. It can be used to detect total GPR61 receptors in Western blots independent of phosphorylation. The GPR61 antibody...
$ 375.00 *
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For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

For more information on orphan receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE,... read more »
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Orphan Receptor Antibodies

For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

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