pS339-P2Y4 (phospho-P2Y Purinoceptor 4 Antibody)

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Agonist-induced Serine339 phosphorylation of the P2Y Receptor 4

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Order number: 7TM0325A
Content: 100 µl
Host: Rabbit

Serine339 (S339) is a major phosphorylation site of the P2Y4 receptor.... more

Serine339 (S339) is a major phosphorylation site of the P2Y4 receptor. The pS339-P2Y4 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. S339 phosphorylation is a key regulator of P2Y4 desensitization, β-arrestin recruitment and internalization.

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Alternative Names P2Y4, P2Y Purinoceptor 4, Pyrimidinergic Receptor P2Y4... more

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Alternative Names	P2Y4, P2Y Purinoceptor 4, Pyrimidinergic Receptor P2Y4
IUPHAR Target ID	325
UniProt ID	P51582
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human P2Y4 around the phosphorylation site of Ser339.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine339 phosphorylation of the P2Y Receptor 4. Upper panel,... more

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Figure 1. Agonist-induced Serine339 phosphorylation of the P2Y Receptor 4. Upper panel, HEK293 cells stably expressing the P2Y Receptor 4 (P2Y4) were either not exposed or exposed to 1 µM ATP (Adenosintriphosphate) or 0.1 μM PMA (Phorbol 12-Myristate 13-Acetate) for 30 minutes. Cells were lysed and immunoblotted with the anti-pS339-P2Y4 antibody (7TM00325A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-P2Y4 antibody to confirm equal loading of the gel.

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