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pT351-P2Y4 (phospho-P2Y Purinoceptor 4 Antibody)

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Agonist-induced Threonine351 phosphorylation of the P2Y Receptor 4
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  • 7TM0325C
  • 100 µl
  • Rabbit
Threonine351 (T351) is a major phosphorylation site of the P2Y4 receptor.... more

Threonine351 (T351) is a major phosphorylation site of the P2Y4 receptor. The pT351-P2Y4 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. T351 phosphorylation is a key regulator of P2Y4 desensitization, β-arrestin recruitment and internalization.

  Alternative Names P2Y4, P2Y Purinoceptor 4, Pyrimidinergic Receptor P2Y4... more

 

Alternative Names P2Y4, P2Y Purinoceptor 4, Pyrimidinergic Receptor P2Y4
IUPHAR Target ID  325
UniProt ID  P51582
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human P2Y4 around the phosphorylation site of Thr351.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Threonine351 phosphorylation of the P2Y Receptor 4. Upper panel,... more

Figure 1. Agonist-induced Threonine351 phosphorylation of the P2Y Receptor 4. Upper panel, HEK293 cells stably expressing the P2Y Receptor 4 (P2Y4) were either not exposed or exposed to 1 µM ATP (Adenosintriphosphate) or 0.1 μM PMA (Phorbol 12-Myristate 13-Acetate) for 30 minutes. Cells were lysed and immunoblotted with the anti-pT351-P2Y4 antibody (7TM00325C) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-P2Y4 antibody to confirm equal loading of the gel.


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