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Somatostatin Receptor Antibodies

Somatostatin receptors are activated by somatotropin-release inhibiting factor (SRIF) that exerts potent inhibitory actions on hormone secretion and neuronal excitability. The somatostatin receptor family consists of five members designated somatostatin receptors 1-5 (SST1-SST5). SST2 is the pharmacological target for octreotide (Sandostatin) which is the first line medical treatment for growth hormone (GH)-producing adenomas (acromegaly) and gastrointestinal neuroendocrine tumors (NET). SST5 is the primary pharmacological target for pasireotide (Signifor) which is the first line medical treatment for adrenocorticotropic hormone (ACTH)-producing adenomas (Cushing’s disease). In addition, SST2 is a prototypical GPCR for the development of peptide-based radiopharmaceuticals for diagnostic and therapeutic interventions of human tumors.

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Agonist-induced Threonine353/Threonine354 phosphorylation of the Somatostatin Receptor 2.
pT353/pT354-SST2 (phospho-Somatostatin Receptor...
Threonine353/Threonine354 (T353/T354) is a major phosphorylation site of the somatostatin receptor 2 (SST2). The pT353/pT354-SST2 antibody detects phosphorylation in response to high-efficacy agonists such as octreotide and low-efficacy...
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Citations
Agonist-induced Threonine356/Threonine359 phosphorylation of the Somatostatin Receptor 2.
pT356/pT359-SST2 (phospho-Somatostatin Receptor...
Threonine356/Threonine359 (T356/T359) is a major phosphorylation site of the somatostatin receptor 2 (SST2). The pT356/pT359-SST2 antibody detects phosphorylation in response to high-efficacy agonists such as octreotide and low-efficacy...
$ 375.00 *
Details
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For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to:

Günther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp HJ, Lupp A, Korbonits M, Castaño JP, Wester HJ, Culler M, Melmed S, Schulz S. International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature. Pharmacol Rev. 2018 Oct;70(4):763-835. doi: 10.1124/pr.117.015388. Review. PubMed PMID: 30232095; PubMed Central PMCID: PMC6148080.

For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to: Günther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp... read more »
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Somatostatin Receptor Antibodies

For more information on somatostatin receptor pharmacology please refer to IUPHAR database. For further reading refer to:

Günther T, Tulipano G, Dournaud P, Bousquet C, Csaba Z, Kreienkamp HJ, Lupp A, Korbonits M, Castaño JP, Wester HJ, Culler M, Melmed S, Schulz S. International Union of Basic and Clinical Pharmacology. CV. Somatostatin Receptors: Structure, Function, Ligands, and New Nomenclature. Pharmacol Rev. 2018 Oct;70(4):763-835. doi: 10.1124/pr.117.015388. Review. PubMed PMID: 30232095; PubMed Central PMCID: PMC6148080.

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