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pS360-TRH1 (phospho-Thyrotropin-Releasing Hormone Receptor 1 Antibody)

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Agonist-induced Serine360 phosphorylation of the TRH1-Receptor
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  • 7TM0363A
  • 100 µl
  • Rabbit
Serine360 (S360) is a major phosphorylation site of the TRH1 receptor. The pS360-TRH1... more

Serine360 (S360) is a major phosphorylation site of the TRH1 receptor. The pS360-TRH1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S360 phosphorylation is primarily mediated by GRKs and is a key regulator of TRH1 desensitization, β-arrestin recruitment and internalization.

  Alternative Names TRH receptor, Thyroliberin receptor, TRH-R1 IUPHAR... more

 

Alternative Names TRH receptor, Thyroliberin receptor, TRH-R1
IUPHAR Target ID  363
UniProt ID  P34981
Western Blot (WB)  1:1000
Immunocytochemistry (ICC)  -
Species Reactivity   Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human TRH1 around the phosphorylation site of Ser360.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine360 phosphorylation of the TRH1-Receptor. Upper panel, HEK293... more

Figure 1. Agonist-induced Serine360 phosphorylation of the TRH1-Receptor. Upper panel, HEK293 cells stably expressing the TRH1-Receptor (TRH1) were either not exposed or exposed to 1 µM of specific TRH1 agonist Taltirelin for 30 minutes. Cells were lysed and immunoblotted with the anti-pS360-TRH1 antibody (7TM0363A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-TRH1 antibody to confirm equal loading of the gel.

Be the first to decipher the TRH1 phosphorylation barcode and let us know. more

Be the first to decipher the TRH1 phosphorylation barcode and let us know.

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