pT371-TRH1 (phospho-Thyrotropin-Releasing Hormone Receptor 1 Antibody)

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Agonist-induced Threonine371 phosphorylation of the TRH1-Receptor

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Order number: 7TM0363C
Content: 100 µl
Host: Rabbit

Threonine371 (T371) is a major phosphorylation site of the TRH1 receptor. The pT371-TRH1... more

Threonine371 (T371) is a major phosphorylation site of the TRH1 receptor. The pT371-TRH1 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T371 phosphorylation is primarily mediated by GRKs and is a key regulator of TRH1 desensitization, β-arrestin recruitment and internalization.

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Alternative Names TRH receptor, Thyroliberin receptor, TRH-R1 IUPHAR... more

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Alternative Names	TRH receptor, Thyroliberin receptor, TRH-R1
IUPHAR Target ID	363
UniProt ID	P34981
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human TRH1 around the phosphorylation site of Thr371.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Threonine371 phosphorylation of the TRH1-Receptor. Upper panel,... more

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Figure 1. Agonist-induced Threonine371 phosphorylation of the TRH1-Receptor. Upper panel, HEK293 cells stably expressing the TRH1-Receptor (TRH1) were either not exposed or exposed to 1 µM of specific TRH1 agonist Taltirelin for 30 minutes. Cells were lysed and immunoblotted with the anti-pT371-TRH1 antibody (7TM0363C) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-TRH1 antibody to confirm equal loading of the gel.

Be the first to decipher the TRH1 phosphorylation barcode and let us know. more

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Be the first to decipher the TRH1 phosphorylation barcode and let us know.

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