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Premium Immunohistochemistry-Grade 7TM Antibodies

G protein-coupled recptors (GPCRs) and heptahelical receptors (7TMR) are notoriously difficult to detect in fixed tissues using antibodies. For many of these receptors the cellular and subcellular localization remains a major challenge. 7TM Antibodies provides highly-characterized protein binding reagents for selected human and rodent GPCRs, which are well suited for efficient localization in formalin-fixed, paraffin-embedded tissues. Each of these antibodies has gone through advanced validation in transfected cells and native tissues using Western blot and immunohistochemistry. Where ever species cross-reactivity allowed, the verification process included validation using knockout mice (KO-Validated). We strictly adhere to the IUPHAR guidelines for receptor nomenclature.

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Citations
KO-Validated
Immunohistochemical identification of Somatostatin Receptor 2 in human neuroendocrine tumor tissue
SST2 (IHC-grade), Somatostatin Receptor 2 Antibody
The SST2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human Somatostatin Receptor 2. It detects selectively the canonical form of SST2 (also referred to as SST2A) and not the...
$ 375.00 *
Details
Citations
Immunohistochemical identification of Somatostatin Receptor 1 in human pituitary
SST1 (IHC-grade), Somatostatin Receptor 1 Antibody
The SST1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Somatostatin Receptor 1. It can be used to detect total SST1 receptors in Western blots independent of phosphorylation. The SST1...
$ 375.00 *
Details
Citations
KO-Validated
Immunohistochemical identification of µ-Opioid Receptor in spinal cord dorsal horn.
MOP (IHC-grade), µ-Opioid Receptor Antibody
The µ-Opioid Receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human MOP. It detects selectively the canonical form of MOP and none of the putative splice variants. In can be used to...
$ 375.00 *
Details
Citations
Immunohistochemical identification of Neurotensin Receptor 2 in gastric mucosa
NTS2 (IHC-grade), Neurotensin Receptor 2 Antibody
The NTS2 antibody is directed against the distal end of the carboxyl-terminal tail of human Neurotensin Receptor 2. It can be used to detect total NTS2 receptors in Western blots independent of phosphorylation. The NTS2 antibody can also...
$ 375.00 *
Details
Citations
Immunohistochemical identification of Endothelin Receptor A in mouse heart
ETA (IHC-grade), Endothelin Receptor A Antibody
The ETA receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human endothelin receptor A. It can be used to detect ETA receptors in Western blots in a phosphorylation-sensitive manner...
$ 375.00 *
Details
Citations
KO-Validated
Immunohistochemical identification of CXC Chemokine Receptor 4 receptor in human lymphoma.
CXCR4 (IHC-grade), CXC Chemokine Receptor 4...
The CXCR4 receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human CXCR4. It can be used to detect CXCR4 receptors in Western blots in a phosphorylation-sensitive manner. After agonist...
$ 375.00 *
Details
Rabbit Monoclonal
NEW
Immunohistochemical identification of Dopamine Receptor 1 in striatum
D1 [UMB10] (RM-IHC-grade), Dopamine Receptor 1...
The non-phospho-D1 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human D1. It can be used to detect total D1 receptors in Western blots independent of phosphorylation. The non-phospho-D1 antibody...
$ 495.00 *
Details
Rabbit Monoclonal
NEW
Immunohistochemical identification of Somatostatin Receptor 4 in parathyroid adenoma
SST4 [UMB9] (RM-IHC-grade), Somatostatin...
The SST4 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Somatostatin Receptor 4. In can be used to detect total SST4 receptors in Western blots independent of phosphorylation. The SST4...
$ 495.00 *
Details
NEW
Immunohistochemical identification of Dopamine Receptor 5 in human cortex
D5 (IHC-grade), Dopamine Receptor 5 Antibody
The D5 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human D5. It can be used to detect total D5 receptors in Western blots independent of phosphorylation. The D5 antibody can also be used to...
$ 375.00 *
Details
Citations
Immunohistochemical identification of Bombesin receptor 3 in human ovarian carcinoma.
BB3 (IHC-grade), Bombesin Receptor 3 Antibody
The BB3 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Bombesin Receptor 3. It can be used to detect BB3 in formalin-fixed, paraffin-embedded tissue sections by immunohistochemistry. It can be...
$ 375.00 *
Details
Rabbit Monoclonal
KO-Validated
NEW
Immunohistochemical identification of CXC Chemokine Receptor 4 in human endometrial carcinoma.
CXCR4 [UMB22] (RM-IHC-grade), CXC Chemokine...
The CXCR4 receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human CXCR4. It can be used to detect CXCR4 receptors in Western blots in a phosphorylation-sensitive manner. After agonist...
$ 495.00 *
Details
Rabbit Monoclonal
KO-Validated
NEW
Immunohistochemical identification of Somatostatin Receptor 2 in human neuroendocrine tumor tissue.
SST2 [UMB11] (RM-IHC-grade), Somatostatin...
The SST2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human Somatostatin Receptor 2. It detects selectively the canonical form of SST2 (also referred to as SST2A) and not the...
$ 495.00 *
Details
Rabbit Monoclonal
KO-Validated
NEW
Immunohistochemical identification of Somatostatin Receptor 5 in human pancreatic islets
SST5 [UMB44] (RM-IHC-grade), Somatostatin...
The SST5 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Somatostatin Receptor 5. In can be used to detect total SST5 receptors in Western blots independent of phosphorylation. The SST5...
$ 495.00 *
Details
Rabbit Monoclonal
KD-Validated
NEW
Immunohistochemical identification of Somatostatin Receptor 3 in human growth-hormone-producing pituitary adenoma tissue.
SST3 [UMB5] (RM-IHC-grade), Somatostatin...
The SST3 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Somatostatin Receptor 3. In can be used to detect total SST3 receptors in Western blots independent of phosphorylation. The SST3...
$ 495.00 *
Details
Rabbit Monoclonal
KD-Validated
NEW
Immunohistochemical identification of Somatostatin Receptor 1 in human pituitary.
SST1 [UMB7] (RM-IHC-grade), Somatostatin...
The SST1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Somatostatin Receptor 1. It can be used to detect total SST1 receptors in Western blots independent of phosphorylation. The SST1...
$ 495.00 *
Details
Rabbit Monoclonal
KO-Validated
NEW
Immunohistochemical identification of µ-Opioid Receptor in caudate putamen.
MOP [UMB3] (RM-IHC-grade), µ-Opioid Receptor...
The µ-Opioid Receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human MOP. It detects selectively the canonical form of MOP and none of the putative splice variants. In can be used to...
$ 495.00 *
Details
5 From 8

For further reading refer to:

Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1. J Clin Endocrinol Metab. 2008 Nov;93(11):4519-24. doi: 10.1210/jc.2008-1063. Epub 2008 Aug 12. PubMed PMID: 18697876.

Fischer T, Nagel F, Jacobs S, Stumm R, Schulz S. Reassessment of CXCR4 chemokine receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-2. PLoS One. 2008;3(12):e4069. doi: 10.1371/journal.pone.0004069. Epub 2008 Dec 31. PubMed PMID: 19116653; PubMed Central PMCID: PMC2605258.

Lupp A, Hunder A, Petrich A, Nagel F, Doll C, Schulz S. Reassessment of sst(5) somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4. Neuroendocrinology. 2011;94(3):255-64. doi: 10.1159/000329876. Epub 2011 Sep 27. PubMed PMID: 21952553.

Lupp A, Richter N, Doll C, Nagel F, Schulz S. UMB-3, a novel rabbit monoclonal antibody, for assessing μ-opioid receptor expression in mouse, rat and human formalin-fixed and paraffin-embedded tissues. Regul Pept. 2011 Feb 25;167(1):9-13. doi: 10.1016/j.regpep.2010.09.004. Epub 2010 Sep 17. PubMed PMID: 20851148.

Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R. ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin. Cell Rep. 2019 Feb 5;26(6):1473-1488.e9. doi: 10.1016/j.celrep.2019.01.049. PubMed PMID: 30726732.

Sánchez-Alcañiz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, López-Bendito G, Stumm R, Marín O. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron. 2011 Jan 13;69(1):77-90. doi: 10.1016/j.neuron.2010.12.006. PubMed PMID: 21220100.

Casar-Borota O, Heck A, Schulz S, Nesland JM, Ramm-Pettersen J, Lekva T, Alafuzoff I, Bollerslev J. Expression of SSTR2a, but not of SSTRs 1, 3, or 5 in somatotroph adenomas assessed by monoclonal antibodies was reduced by octreotide and correlated with the acute and long-term effects of octreotide. J Clin Endocrinol Metab. 2013 Nov;98(11):E1730-9. doi: 10.1210/jc.2013-2145. Epub 2013 Oct 3. PubMed PMID: 24092823.

Lee M, Lupp A, Mendoza N, Martin N, Beschorner R, Honegger J, Schlegel J, Shively T, Pulz E, Schulz S, Roncaroli F, Pellegata NS. SSTR3 is a putative target for the medical treatment of gonadotroph adenomas of the pituitary. Endocr Relat Cancer. 2015 Feb;22(1):111-9. doi: 10.1530/ERC-14-0472. Epub 2014 Dec 16. PubMed PMID: 25515731.

For further reading refer to: Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the... read more »
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Premium Immunohistochemistry-Grade 7TM Antibodies

For further reading refer to:

Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1. J Clin Endocrinol Metab. 2008 Nov;93(11):4519-24. doi: 10.1210/jc.2008-1063. Epub 2008 Aug 12. PubMed PMID: 18697876.

Fischer T, Nagel F, Jacobs S, Stumm R, Schulz S. Reassessment of CXCR4 chemokine receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-2. PLoS One. 2008;3(12):e4069. doi: 10.1371/journal.pone.0004069. Epub 2008 Dec 31. PubMed PMID: 19116653; PubMed Central PMCID: PMC2605258.

Lupp A, Hunder A, Petrich A, Nagel F, Doll C, Schulz S. Reassessment of sst(5) somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4. Neuroendocrinology. 2011;94(3):255-64. doi: 10.1159/000329876. Epub 2011 Sep 27. PubMed PMID: 21952553.

Lupp A, Richter N, Doll C, Nagel F, Schulz S. UMB-3, a novel rabbit monoclonal antibody, for assessing μ-opioid receptor expression in mouse, rat and human formalin-fixed and paraffin-embedded tissues. Regul Pept. 2011 Feb 25;167(1):9-13. doi: 10.1016/j.regpep.2010.09.004. Epub 2010 Sep 17. PubMed PMID: 20851148.

Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R. ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin. Cell Rep. 2019 Feb 5;26(6):1473-1488.e9. doi: 10.1016/j.celrep.2019.01.049. PubMed PMID: 30726732.

Sánchez-Alcañiz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, López-Bendito G, Stumm R, Marín O. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron. 2011 Jan 13;69(1):77-90. doi: 10.1016/j.neuron.2010.12.006. PubMed PMID: 21220100.

Casar-Borota O, Heck A, Schulz S, Nesland JM, Ramm-Pettersen J, Lekva T, Alafuzoff I, Bollerslev J. Expression of SSTR2a, but not of SSTRs 1, 3, or 5 in somatotroph adenomas assessed by monoclonal antibodies was reduced by octreotide and correlated with the acute and long-term effects of octreotide. J Clin Endocrinol Metab. 2013 Nov;98(11):E1730-9. doi: 10.1210/jc.2013-2145. Epub 2013 Oct 3. PubMed PMID: 24092823.

Lee M, Lupp A, Mendoza N, Martin N, Beschorner R, Honegger J, Schlegel J, Shively T, Pulz E, Schulz S, Roncaroli F, Pellegata NS. SSTR3 is a putative target for the medical treatment of gonadotroph adenomas of the pituitary. Endocr Relat Cancer. 2015 Feb;22(1):111-9. doi: 10.1530/ERC-14-0472. Epub 2014 Dec 16. PubMed PMID: 25515731.

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