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pT379-MOP (IHC-grade phospho-µ-Opioid Receptor Antibody)

Citations
NEW
KO-Validated
 Immunohistochemical Identification of Agonist-induced Threonine379 phosphorylation of the µ-Opioid Receptor in mouse spinal cord
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  • 7TM0319E-IC
  • 300 µl
  • Rabbit
Threonine379 (T379) is a major phosphorylation site of the µ-opioid receptor (MOP). The... more

Threonine379 (T379) is a major phosphorylation site of the µ-opioid receptor (MOP). The pT379-MOP antibody detects phosphorylation in response to high-efficacy agonists but to low-efficacy agonists or after PKC activation. T379 phosphorylation is a key regulator of MOP desensitization, β-arrestin recruitment and tolerance. The pT379-MOP antibody can detect phosphorylated MOP in mouse brain in vivo.

  Alternative Names MOP, OPRM1, µ-Opioid Receptor, Mu Receptor IUPHAR... more

 

Alternative Names MOP, OPRM1, µ-Opioid Receptor, Mu Receptor
IUPHAR Target ID  319
UniProt ID  P35372 (human) P42866 (mouse) P33535 (rat)
Immunohistochemistry (IHC)  1:50
Species Reactivity   Human, Mouse, Rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human MOP around the phosphorylation site of Thr379.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Immunohistochemical Identification of Agonist-induced Threonine379 phosphorylation of... more

Figure 1. Immunohistochemical Identification of Agonist-induced Threonine379 phosphorylation of the µ-Opioid Receptor in mouse spinal cord. Mice were either injected subcutaneously with saline or fentanyl citrate (0,3 mg/kg bodyweight) for 15 min. Animals were then transcardially perfused, fixed  and stained in presence of phosphatase and protease inhibitors. Shown are confocal images of coronal sections of the spinal cord stained with the anti-pT379-MOP antibody (7TM0319E-IC).

Fritzwanker S, Nagel F, Kliewer A, Stammer V, Schulz S. In situ visualization of opioid and... more

Fritzwanker S, Nagel F, Kliewer A, Stammer V, Schulz S. In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies. Commun Biol. 2023 Apr 15;6(1):419. doi: 10.1038/s42003-023-04786-2. PMID: 37061609; PMCID: PMC10105690.

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