pS355/pS360-ACKR3 (phospho-Atypical Chemokine Receptor 3 Antibody)

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Agonist-induced Serine355/Serine360 phosphorylation of the Atypical Chemokine Receptor 3/CXC Chemokine Receptor 7

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Order number: 7TM0080B
Content: 100 µl
Host: Rabbit

Serine355/Serine360 (S355/S360) is major phosphorylation site of the Atypical Chemokine Receptor... more

Serine355/Serine360 (S355/S360) is major phosphorylation site of the Atypical Chemokine Receptor 3 (ACKR3, previously called CXCR7). The pS355/pS360-ACKR3 antibody detects phosphorylation in response to agonists. S355/S360 phosphorylation is required for efficient ligand sequestration by ACKR3.

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Alternative Names ACKR3, CXCR7, Atypical Chemokine Receptor 3, CXC... more

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Alternative Names	ACKR3, CXCR7, Atypical Chemokine Receptor 3, CXC Chemokine Receptor 7
IUPHAR Target ID	80
UniProt ID	P25106 (human) P56485 (mouse)
Western Blot (WB)	1:1000
Species Reactivity	Human, Mouse
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human ACKR3 around the phosphorylation site of Ser355/Ser360.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine355/Serine360 phosphorylation of the Atypical Chemokine... more

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Figure 1. Agonist-induced Serine355/Serine360 phosphorylation of the Atypical Chemokine Receptor 3/CXC Chemokine Receptor 7. Upper panel, HEK293 cells stably expressing the Atypical Chemokine Receptor 3/CXC Chemokine Receptor 7 (ACKR3/CXCR7) were either not exposed or exposed to 100 nM CXCL12 or 0.1 μM VUF 11207 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS355/pS360-ACKR3/CXCR7 antibody (7TM0080B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-ACKR3/CXCR7 antibody (7TM0080N) at a dilution of 1:1000 to confirm equal loading of the gel.

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