ACKR3 (non-phos, C-Term), Atypical Chemokine Receptor 3 Antibody

Validation of the Atypical Chemokine Receptor 3/CXC Chemokine Receptor 7 in transfected HEK293 cells.

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Order number: 7TM0080N
Content: 100 µl
Host: Rabbit

The non-phospho-ACKR3 receptor antibody is directed against the carboxyl-terminal tail of mouse,... more

The non-phospho-ACKR3 receptor antibody is directed against the carboxyl-terminal tail of mouse, rat and human ACKR3/CXCR7. It can be used to detect total ACKR3 receptors in Western blots independent of phosphorylation. The non-phospho-ACKR3 antibody can also be used to isolate and enrich ACKR3 receptors from cell and tissue lysates.

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Alternative Names ACKR3, CXCR7, Atypical Chemokin Receptor 3, CXC Chemokin... more

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Alternative Names	ACKR3, CXCR7, Atypical Chemokin Receptor 3, CXC Chemokin Receptor 7
IUPHAR Target ID	80
UniProt ID	P25106(human) P56485 (mouse) O89039 (rat)
Western Blot (WB)	1:1000
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic peptide presents part of carboxyl-terminal tail which is identical in human, mouse and rat ACKR3
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Validation of the Atypical Chemokine Receptor 3/CXC Chemokine Receptor 7 in... more

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Figure 1. Validation of the Atypical Chemokine Receptor 3/CXC Chemokine Receptor 7 in transfected HEK293 cells. Native HEK293 cells (MOCK) or HEK293 cells stably expressing the Atypical Chemokine Receptor 3/CXC Chemokine Receptor 7 (ACKR3) were lysed and immunoblotted with the phosphorylation-independent c-terminal anti-ACKR3/CXCR7 antibody (7TM0080N) at a dilution of 1:1000. Note, ACKR3/CXCR7 forms stable dimers and multimers.

Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM,... more

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Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R. ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin. Cell Rep. 2019 Feb 5;26(6):1473-1488.e9. doi: 10.1016/j.celrep.2019.01.049. PubMed PMID: 30726732.

Sánchez-Alcañiz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, López-Bendito G, Stumm R, Marín O. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron. 2011 Jan 13;69(1):77-90. doi: 10.1016/j.neuron.2010.12.006. PubMed PMID: 21220100.

Hoffmann F, Müller W, Schütz D, Penfold ME, Wong YH, Schulz S, Stumm R. Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues. J Biol Chem. 2012 Aug 17;287(34):28362-77. doi: 10.1074/jbc.M111.335679. Epub 2012 Jun 26. PubMed PMID: 22736769; PubMed Central PMCID: PMC3436560.