pS339/pS340-CX3CR1 (phospho-CX3CR1 Chemokine Receptor Antibody)

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Agonist-induced Serine339/Serine340 phosphorylation of the Chemokine Receptor CX3CR1

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Order number: 7TM0074B
Content: 100 µl
Host: Rabbit

Serine339/Serine340 (S339/S340) is a major phosphorylation site of the CX3CR1 receptor.... more

Serine339/Serine340 (S339/S340) is a major phosphorylation site of the CX3CR1 receptor. The pS339/pS340-CX3CR1 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. S339/S340 phosphorylation is a key regulator of CX3CR1 desensitization, β-arrestin recruitment and internalization.

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Alternative Names CMKBRL1, CCRL1, chemokine (C-3X-C motif) receptor 1... more

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Alternative Names	CMKBRL1, CCRL1, chemokine (C-3X-C motif) receptor 1
IUPHAR Target ID	74
UniProt ID	P49238
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human CCR5 around the phosphorylation site of Ser339/Ser340.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine339/Serine340 phosphorylation of the Chemokine Receptor... more

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Figure 1. Agonist-induced Serine339/Serine340 phosphorylation of the Chemokine Receptor CX3CR1. Upper panel, HEK293 cells stably expressing the Chemokine Receptor CX3CR1 (CX3CR1) were either not exposed or exposed to 100 nM specific Chemokine receptor CX3CR1 agonist CX3CL1 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS339/pS340-CX3CR1 antibody (7TM0074B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-CX3CR1 antibody (7TM0074N) to confirm equal loading of the gel.

Be the first to decipher the CX3CR1 phosphorylation barcode and let us know. more

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Be the first to decipher the CX3CR1 phosphorylation barcode and let us know.

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