pS353/pT356-CXCR2 (phospho-CXC Chemokine Receptor 2 Antibody)

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Agonist-induced Serine353/Threonine356 phosphorylation of the CXC Chemokine Receptor 2

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Order number: 7TM0069C
Content: 100 µl
Host: Rabbit

Serine353/Threonine356 (S353/T356) is a major phosphorylation site of the CXCR2 receptor.... more

Serine353/Threonine356 (S353/T356) is a major phosphorylation site of the CXCR2 receptor. The pS353/pT356-CXCR2 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. S353/T356 phosphorylation is a key regulator of CXCR2 desensitization, β-arrestin recruitment and internalization.

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Alternative Names CXC-R2, high affinity interleukin-8 Receptor B, Chemokine... more

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Alternative Names	CXC-R2, high affinity interleukin-8 Receptor B, Chemokine (C-X-C motif) Receptor 2
IUPHAR Target ID	69
UniProt ID	P25025
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human CXCR2 around the phosphorylation site of Ser353/Thr356.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine353/Threonine356 phosphorylation of the CXC Chemokine Receptor... more

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Figure 1. Agonist-induced Serine353/Threonine356 phosphorylation of the CXC Chemokine Receptor 2. Upper panel, HEK293 cells stably expressing the CXC Chemokine Receptor 2 (CXCR2) were either not exposed or exposed to 100 nM specific CXC Chemokine receptor 2 agonist CXCL6 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS353/pT356-CXCR2 antibody (7TM0069C) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-CXCR2 antibody to confirm equal loading of the gel.

Be the first to decipher the CXCR2 phosphorylation barcode and let us know. more

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Be the first to decipher the CXCR2 phosphorylation barcode and let us know.

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