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pS324/pS325-CXCR4 (phospho-CXC Chemokine Receptor 4 Antibody)

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Agonist-induced Serine324/Serine325 phosphorylation of the CXC Chemokine Receptor 4.
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  • 7TM0071A
  • 100 µl
  • Rabbit
Serine324/serine325 (S324/S325) is a major phosphorylation site of the CXCR4 receptor. The... more

Serine324/serine325 (S324/S325) is a major phosphorylation site of the CXCR4 receptor. The pS324/pS325-CXCR4 antibody detects phosphorylation in response to agonists but not after PKC activation. S324/S325 phosphorylation is a key regulator of CXCR4 desensitization, β-arrestin recruitment and internalization.

  Alternative Names CXCR4, CXC Chemokin Receptor 4 IUPHAR Target ID... more

 

Alternative Names CXCR4, CXC Chemokin Receptor 4
IUPHAR Target ID  71
UniProt ID  P61073  (human) P70658 (mouse)
Western Blot (WB)  1:1000
Species Reactivity   Human, Mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human CXCR4 around the phosphorylation site of Ser324/Ser325
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine324/Serine325 phosphorylation of the CXC Chemokine Receptor 4.... more

Figure 1. Agonist-induced Serine324/Serine325 phosphorylation of the CXC Chemokine Receptor 4. Upper panel, HEK293 cells stably expressing the HA-tagged CXC Chemokine Receptor 4 were either not exposed or exposed to 100 nM CXCL12 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS324/pS325-CXCR4 antibody (7TM0071A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-HA antibody (7TM000HA) at a dilution of 1:1000 to confirm equal loading of the gel.

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