pT370/pT371-CXCR5 (phospho-CXC Chemokine Receptor 5 Antibody)

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Agonist-induced Threonine370/Threonine371 phosphorylation of the CXC Chemokine Receptor 5

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Order number: 7TM0072B
Content: 100 µl
Host: Rabbit

Threonine370/Threonine371 (T370/T371) is a major phosphorylation site of the CXCR5 receptor.... more

Threonine370/Threonine371 (T370/T371) is a major phosphorylation site of the CXCR5 receptor. The pT370/pT371-CXCR5 antibody detects phosphorylation in response to high- and low-efficacy agonists but not after PKC activation. T370/T371 phosphorylation is a key regulator of CXCR5 desensitization, β-arrestin recruitment and internalization.

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Alternative Names CXCR5, BLR-1, Burkitt lymphoma Receptor 1, Neurolymphatic... more

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Alternative Names	CXCR5, BLR-1, Burkitt lymphoma Receptor 1, Neurolymphatic Receptor
IUPHAR Target ID	72
UniProt ID	P32302
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human CXCR5 around the phosphorylation site of Thr370/Thr371.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Threonine370/Threonine371 phosphorylation of the CXC Chemokine... more

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Figure 1. Agonist-induced Threonine370/Threonine371 phosphorylation of the CXC Chemokine Receptor 5. Upper panel, HEK293 cells stably expressing the CXC Chemokine Receptor 5 (CXCR5) were either not exposed or exposed to 100 nM specific CXC Chemokine receptor agonist CXCL13 for 30 minutes. Cells were lysed and immunoblotted with the anti-pT370/pT371-CXCR5 antibody (7TM0072B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-CXCR5 antibody to confirm equal loading of the gel.

Be the first to decipher the CXCR5 phosphorylation barcode and let us know. more

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Be the first to decipher the CXCR5 phosphorylation barcode and let us know.

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