pS338/pT339-FPR1 (phospho-Formylpeptide Receptor 1 Antibody)

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Agonist-induced Serine338/Threonine339 phosphorylation of Formylpeptide Receptor 1

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Order number: 7TM0222A
Content: 100 µl
Host: Rabbit

Serine338/Threonine339 (S338/T339) is a major phosphorylation site of the Formylpeptide... more

Serine338/Threonine339 (S338/T339) is a major phosphorylation site of the Formylpeptide Receptor 1 (FPR1). The pS338/pT339-FPR1 antibody detects phosphorylation in response to high-efficacy agonists. S338/T339 phosphorylation is a key regulator of FPR1 desensitization, β-arrestin recruitment and internalization.

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Alternative Names NFPR, fMLF-R, Formyl Peptide Receptor 1 IUPHAR... more

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Alternative Names	NFPR, fMLF-R, Formyl Peptide Receptor 1
IUPHAR Target ID	222
UniProt ID	P21462
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human FPR1 around the phosphorylation site Ser338/Ser339.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine338/Threonine339 phosphorylation of Formylpeptide Receptor 1.... more

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Figure 1. Agonist-induced Serine338/Threonine339 phosphorylation of Formylpeptide Receptor 1. Upper panel, HEK293 cells stably expressing the Formylpeptide-Receptor 1 (FPR1) were either not exposed or exposed to 1 µM of specific FPR-Receptor agonist WKYMVm for 30 minutes. Cells were lysed and immunoblotted with the anti-pS338/pS339-FPR1 antibody (7TM0222A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-FPR1 antibody to confirm equal loading of the gel.