pT335/pS338-MCH2 (phospho-Melanin-Concentrating Hormone Receptor 2 Antibody)

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Agonist-induced Threonine335/Serine338 phosphorylation of MCH2 Receptor

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Order number: 7TM0281A
Content: 100 µl
Host: Rabbit

Threonine335/Serine338 (T335/S338) is a major phosphorylation site of the MCH2 receptor.... more

Threonine335/Serine338 (T335/S338) is a major phosphorylation site of the MCH2 receptor. The pT335/pS338-MCH2 antibody detects phosphorylation in response to high-efficacy agonists. T335/S338 phosphorylation is a key regulator of MCH2 desensitization, β-arrestin recruitment and internalization.

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Alternative Names GPR145, GPRv17, MCH2R, melanin-concentrating hormone... more

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Alternative Names	GPR145, GPRv17, MCH2R, melanin-concentrating hormone receptor 2
IUPHAR Target ID	281
UniProt ID	Q969V1
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human MCH2 around the phosphorylation site Thr335/Ser338.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Threonine335/Serine338 phosphorylation of MCH2 Receptor. Upper... more

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Figure 1. Agonist-induced Threonine335/Serine338 phosphorylation of MCH2 Receptor. Upper panel, HEK293 cells stably expressing the MCH2-Receptor (MCH2) were either not exposed or exposed to 1 µM of MCH2-Receptor agonist MCH for 30 minutes. Cells were lysed and immunoblotted with the anti-pT335/pS338-MCH2 antibody (7TM0281A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-MCH2 antibody to confirm equal loading of the gel.

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