![Agonist-induced Serine492/Serine493 phosphorylation of the Parathyroid Hormone Receptor 1](https://7tmantibodies.com/media/image/10/a9/42/pS492-pS493-PTH1-F1-NEW_600x600.png)
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- Order number: 7TM0331C
- Content: 100 µl
- Host: Rabbit
Serine492/Serine493 (S492/S493) is major phosphorylation site of the Parathyroid Hormone Receptor 1 (PTH1). The pS492/pS493-PTH1 antibody detects phosphorylation in response to agonists. S492/S493 phosphorylation is likely to be involved in efficient ligand sequestration by PTH1.
Alternative Names | PPR, PTHR |
IUPHAR Target ID | 331 |
UniProt ID | Q03431 |
Western Blot (WB) | 1:1000 |
Species Reactivity | Human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Immunogen | A synthetic phosphopeptide derived from human PTH1 around the phosphorylation site of Ser492/Ser493. |
Form | Liquid |
Purification | Antigen affinity chromatography |
Storage buffer | Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide |
Storage conditions | short-term 4°C, long-term -20°C |
Figure 1. Agonist-induced Serine492/Serine493 phosphorylation of the Parathyroid Hormone Receptor 1. Upper panel, HEK293 cells stably expressing the Prathyroid Hormone receptor 1 (PTH1) were either not exposed or exposed to 100 nM PTH for 30 minutes. Cells were lysed and immunoblotted with the anti-pS492/pS493-PTH1 antibody (7TM0331C) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-PTH1 antibody (7TM0331N) to confirm equal loading of the gel.
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