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CXCR4 (GP-non-phospho), CXC Chemokine Receptor 4 Antibody, Guinea Pig

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CXCR4 (GP-non-phospho), CXC Chemokine Receptor 4 Antibody, Guinea Pig
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  • Order number: 7TM0071N-GP
  • Content: 100 µl
  • Host: Rabbit
Description Specifications Figure Legends Citations Downloads 4 Evaluations 0
Description
The non-phospho-CXCR4 receptor antibody is directed against the distal end of the... more
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The non-phospho-CXCR4 receptor antibody is directed against the distal end of the carboxyl-terminal tail of mouse, rat and human CXCR4. It can be used to detect CXCR4 receptors in Western blots in a phosphorylation-sensitive manner. It can also be used to isolate and enrich CXCR4 receptors from brain lysates. 

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Specifications
  Alternative Names CXCR4, CXC Chemokin Receptor 4 IUPHAR Target ID... more
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Alternative Names CXCR4, CXC Chemokin Receptor 4
IUPHAR Target ID  71
UniProt ID  P61073  (human) P70658 (mouse) O08565 (rat)
Western Blot (WB)  1:1000
Species Reactivity   Human, Mouse, Rat
Host / Isotype Guinea Pig / IgG
Class Polyclonal
Immunogen A synthetic peptide with the sequence KGKRGGHSSVSTESESSSFHSS corresponding to residues 338-359 in human, mouse and rat CXCR4
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure Legends
Figure 1. Validation of the CXC Chemokine Receptor 4 in transfected HEK293 cells . Native... more
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Figure 1. Validation of the CXC Chemokine Receptor 4 in transfected HEK293 cells. Native HEK293 cells (MOCK) or HEK293 cells stably expressing the CXC Chemokine Receptor 4 (CXCR4) were lysed and immunoblotted with the phosphorylation-sensitive anti-CXCR4 antibody (7TM0071N-GP) at a dilution of 1:1000.

Citations
Stumm RK, Rummel J, Junker V, Culmsee C, Pfeiffer M, Krieglstein J, Höllt V, Schulz S. A dual... more
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Stumm RK, Rummel J, Junker V, Culmsee C, Pfeiffer M, Krieglstein J, Höllt V, Schulz S. A dual role for the SDF-1/CXCR4 chemokine receptor system in adult brain: isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia. J Neurosci. 2002 Jul 15;22(14):5865-78. PubMed PMID: 12122049; PubMed Central PMCID: PMC6757949.

Stumm RK, Zhou C, Ara T, Lazarini F, Dubois-Dalcq M, Nagasawa T, Höllt V, Schulz S. CXCR4 regulates interneuron migration in the developing neocortex. J Neurosci. 2003 Jun 15;23(12):5123-30. PubMed PMID: 12832536; PubMed Central PMCID: PMC6741192.

Fischer T, Nagel F, Jacobs S, Stumm R, Schulz S. Reassessment of CXCR4 chemokine receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-2. PLoS One. 2008;3(12):e4069. doi: 10.1371/journal.pone.0004069. Epub 2008 Dec 31. PubMed PMID: 19116653; PubMed Central PMCID: PMC2605258.

Sánchez-Alcañiz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, López-Bendito G, Stumm R, Marín O. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron. 2011 Jan 13;69(1):77-90. doi: 10.1016/j.neuron.2010.12.006. PubMed PMID: 21220100.

Gourni E, Demmer O, Schottelius M, D'Alessandria C, Schulz S, Dijkgraaf I, Schumacher U, Schwaiger M, Kessler H, Wester HJ. PET of CXCR4 expression by a (68)Ga-labeled highly specific targeted contrast agent. J Nucl Med. 2011 Nov;52(11):1803-10. doi: 10.2967/jnumed.111.098798. PubMed PMID: 22045709.

Otte M, Kliewer A, Schütz D, Reimann C, Schulz S, Stumm R. CXCL14 is no direct modulator of CXCR4. FEBS Lett. 2014 Dec 20;588(24):4769-75. doi: 10.1016/j.febslet.2014.11.009. Epub 2014 Nov 18. PubMed PMID: 25451233.

Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R. ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin. Cell Rep. 2019 Feb 5;26(6):1473-1488.e9. doi: 10.1016/j.celrep.2019.01.049. PubMed PMID: 30726732.

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