pS338/pS339-CXCR4 (phospho-CXC Chemokine Receptor 4 Antibody)

NEW

Agonist-induced Serine338/Serine339 phosphorylation of the CXC Chemokine Receptor 4

$ 375.00 *

Ready to ship today,
Delivery time appr. 5-8 days

Order number: 7TM0071D
Content: 100 µl
Host: Rabbit

Serine338 and Serine339 (S338/S339) are a major phosphorylation sites of the CXCR4 receptor.... more

Serine338 and Serine339 (S338/S339) are a major phosphorylation sites of the CXCR4 receptor. The pS338/pS339-CXCR4 antibody detects phosphorylation in response to agonists and after PKC activation. S338/S339 phosphorylation is a key regulator of CXCR4 desensitization, β-arrestin recruitment and internalization.

Available downloads:

Alternative Names CXCR4, CXC Chemokine Receptor 4 IUPHAR Target ID... more

Close menu

Alternative Names	CXCR4, CXC Chemokine Receptor 4
IUPHAR Target ID	71
UniProt ID	P61073 (human) P70658 (mouse)
Western Blot (WB)	1:1000
Species Reactivity	Human, Mouse
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human CXCR4 around the phosphorylation site of Ser338/Ser339.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine338/Serine339 phosphorylation of the CXC Chemokine Receptor 4.... more

Close menu

Figure 1. Agonist-induced Serine338/Serine339 phosphorylation of the CXC Chemokine Receptor 4. HEK293 cells transiently expressing CXC Chemokine Receptor 4 (CXCR4) were either not exposed or exposed to 100 nM CXCL12 for 5 minutes. Cells were lysed and immunoblotted with the anti-pS338/pS339-CXCR4 antibody (7TM0071D) at a dilution of 1:1000 (upper panel). The same lysates were probed with the non-phospho-CXCR4 antibody (7TM0071N) at a dilution of 1:1000 (lower panel).

Close menu