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pS338/pS339-CXCR4 (phospho-CXC Chemokine Receptor 4 Antibody)

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Agonist-induced Serine338/Serine339 phosphorylation of the CXC Chemokine Receptor 4
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  • 7TM0071D
  • 100 µl
  • Rabbit
Serine338 and Serine339 (S338/S339) are a major phosphorylation sites of the CXCR4 receptor.... more

Serine338 and Serine339 (S338/S339) are a major phosphorylation sites of the CXCR4 receptor. The pS338/pS339-CXCR4 antibody detects phosphorylation in response to agonists and after PKC activation. S338/S339 phosphorylation is a key regulator of CXCR4 desensitization, β-arrestin recruitment and internalization.

  Alternative Names CXCR4, CXC Chemokine Receptor 4 IUPHAR Target ID... more

 

Alternative Names CXCR4, CXC Chemokine Receptor 4
IUPHAR Target ID  71
UniProt ID  P61073  (human) P70658 (mouse)
Western Blot (WB)  1:1000
Species Reactivity   Human, Mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Immunogen A synthetic phosphopeptide derived from human CXCR4 around the phosphorylation site of Ser338/Ser339.
Form  Liquid
Purification Antigen affinity chromatography
Storage buffer Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions short-term 4°C, long-term -20°C
Figure 1. Agonist-induced Serine338/Serine339 phosphorylation of the CXC Chemokine Receptor 4.... more

Figure 1. Agonist-induced Serine338/Serine339 phosphorylation of the CXC Chemokine Receptor 4. HEK293 cells transiently expressing CXC Chemokine Receptor 4 (CXCR4) were either not exposed or exposed to 100 nM CXCL12 for 5 minutes. Cells were lysed and immunoblotted with the anti-pS338/pS339-CXCR4 antibody (7TM0071D) at a dilution of 1:1000 (upper panel). The same lysates were probed with the non-phospho-CXCR4 antibody (7TM0071N) at a dilution of 1:1000 (lower panel).

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