pS345/pT346-NK2 (phospho-Tachykinin Receptor 2 Antibody)

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Agonist-induced Serine345/Threonine346 phosphorylation of NK2 Receptor.

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Order number: 7TM0361B
Content: 100 µl
Host: Rabbit

Serine345/Threonine346 (S345/T346) is a major phosphorylation site of the NK2 receptor.... more

Serine345/Threonine346 (S345/T346) is a major phosphorylation site of the NK2 receptor. The pS345/pT346-NK2 antibody detects phosphorylation in response to high-efficacy agonists. S345/T346 phosphorylation is a key regulator of NK2 desensitization, β-arrestin recruitment and internalization.

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Alternative Names NK2, SKR, TACR2, Neurokinin B Receptor, Substance K... more

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Alternative Names	NK2, SKR, TACR2, Neurokinin B Receptor, Substance K Receptor
IUPHAR Target ID	361
UniProt ID	P21452
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human NK2 around the phosphorylation site Ser345/Thr346.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine345/Threonine346 phosphorylation of NK2 Receptor. Upper... more

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Figure 1. Agonist-induced Serine345/Threonine346 phosphorylation of NK2 Receptor. Upper panel, HEK293 cells stably expressing the NK2-Receptor (NK2) were either not exposed or exposed to 1 µM of specific NK2-Receptor agonist Neurokinin B for 30 minutes. Cells were lysed and immunoblotted with the anti-pS345/pT346-NK2 antibody (7TM0361B) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-NK2 antibody to confirm equal loading of the gel.

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