pS450/pS452-PAC1 (phospho-PACAP Receptor 1 Antibody)

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Agonist-induced Serine450/Serine452 phosphorylation of the PACAP Receptor 1

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Order number: 7TM0370C
Content: 100 µl
Host: Rabbit

Serine450/Serine452 (S450/S452) is major phosphorylation site of the PACAP Receptor 1 (PAC1).... more

Serine450/Serine452 (S450/S452) is major phosphorylation site of the PACAP Receptor 1 (PAC1). The pS450/pS452-PAC1 antibody detects phosphorylation in response to agonists. S450/S452 phosphorylation is likely to be involved in efficient ligand sequestration by PAC1.

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Alternative Names PAC1, PVR1, PACAP Receptor 1, Pituitary adenylate cyclase... more

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Alternative Names	PAC1, PVR1, PACAP Receptor 1, Pituitary adenylate cyclase activating polypeptide 1 receptor
IUPHAR Target ID	370
UniProt ID	P41586
Western Blot (WB)	1:1000
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human PAC1 around the phosphorylation site of Ser450/Ser452.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine450/Serine452 phosphorylation of the PACAP Receptor 1. Upper... more

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Figure 1. Agonist-induced Serine450/Serine452 phosphorylation of the PACAP Receptor 1. Upper panel, HEK293 cells stably expressing the PACAP receptor 1 (PAC1) were either not exposed or exposed to 100 nM PACAP for 30 minutes. Cells were lysed and immunoblotted with the anti-pS450/pS452-PAC1 antibody (7TM0370C) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-PAC1 antibody (7TM0370N) to confirm equal loading of the gel.

Be the first to analyze the ACKR2 phosphorylation using our anti-pS348/pS350-ACKR2... more

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Be the first to analyze the ACKR2 phosphorylation using our anti-pS348/pS350-ACKR2 antibody and let us know.

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