P2Y12 (non-phospho) P2Y Purinoceptor 12 Antibody)

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Order number: 7TM0328N
Content: 100 µl
Host: Rabbit

Serine323 (S323) is a major phosphorylation site of the P2Y12 receptor. The pS323-P2Y12... more

Serine323 (S323) is a major phosphorylation site of the P2Y12 receptor. The pS323-P2Y12 antibody detects phosphorylation in response to high- and low-efficacy agonists and after PKC activation. S323 phosphorylation is a key regulator of P2Y12 desensitization, β-arrestin recruitment and internalization.

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Alternative Names P2Y12, P2Y Purinoceptor 12, Purinergic Receptor P2Y12... more

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Alternative Names	P2Y12, P2Y Purinoceptor 12, Purinergic Receptor P2Y12
IUPHAR Target ID	328
UniProt ID	Q9H244
Western Blot (WB)	1:1000
Immunocytochemistry (ICC)	-
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human P2Y12 around the phosphorylation site of Ser323.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine323 phosphorylation of the P2Y Purinoceptor 12. Upper panel,... more

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Figure 1. Agonist-induced Serine323 phosphorylation of the P2Y Purinoceptor 12. Upper panel, HEK293 cells stably expressing the P2Y Purinoceptor 12 (P2Y12) were either not exposed or exposed to 1 µM ATP (Adenosintriphosphate) for 30 minutes. Cells were lysed and immunoblotted with the anti-pS323-P2Y12 antibody (7TM00328A) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent anti-P2Y12 antibody to confirm equal loading of the gel.

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